Analysis of acquired immunity system in insects

昆虫获得性免疫系统分析

• 批准号: 23658053
• 负责人: TANAKA Hiromitsu
• 金额: $ 2.5万
• 依托单位: National Institute of Agrobiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23658053/
• 关键词: 昆虫病理; カイコ; 自然免疫; 免疫記憶

Insects possess an innate immunity system that is characterized as immune reactions with non-specific factors. Although insects are known to lack an acquired immunity with immunological memory, it is still controversy whether insects have an immunological memory or not. In this study, we found that priming silkworm with E. coli increased clearance of living E. coli cells in the E. coli-reinoculated body. Furthermore, we indicated that the elevation of this clearance was not caused by activation of the humoral immune reactions, but probably by activation of the cellular reactions.

昆虫拥有一种先天免疫系统，其特征是对非特定因素的免疫反应。虽然昆虫缺乏具有免疫记忆的获得性免疫，但昆虫是否具有免疫记忆仍存在争议。在这项研究中，我们发现，用大肠杆菌引发家蚕增加了活的大肠杆菌细胞在重新定位的体内的清除。此外，我们还指出，这种清晰度的升高不是由体液免疫反应的激活引起的，而可能是由细胞反应的激活引起的。