Development of diagnosis and treatment method of man sterility based on analyses of spermatogenesis-assaciatal genes

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As many as 15% of couples are unable to conceive, and males are known to be responsible for half of the instances of infertility. Although advances in medical technology have allowed some infertile couples to have children, the causes of infertility are, in most cases, unknown. Many genes are expressed exclusively in the testes, particularly in the testicular germ cells. It is reasonable to propose that functional deficiencies in the genes expressed exclusively in spermatogenesis should lead to male infertility when there is no observable abnormality in the somatic cells of various organs. Hence, in order to understand idiopathic male infertility, development of diagnosis and treatment method of male infertility based on analyses of spermatogenesis-associated genes is essential. In this study, we found infertility specific protein in human semen and identified polymorphisms associated with male infertility in human haploid germ cell specific genes.