Development of diagnosis and treatment method of man sterility based on analyses of spermatogenesis-assaciatal genes

基于精子发生相关基因分析的男性不育症诊治方法的建立

• 批准号: 17209052
• 负责人: TANAKA Hiromitsu
• 金额: $ 31.7万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17209052/
• 关键词: Testis; Sperm; male infertilit; Development; gene; protein; Specific; Treatment; 男性不妊症; SNP

As many as 15% of couples are unable to conceive, and males are known to be responsible for half of the instances of infertility. Although advances in medical technology have allowed some infertile couples to have children, the causes of infertility are, in most cases, unknown. Many genes are expressed exclusively in the testes, particularly in the testicular germ cells. It is reasonable to propose that functional deficiencies in the genes expressed exclusively in spermatogenesis should lead to male infertility when there is no observable abnormality in the somatic cells of various organs. Hence, in order to understand idiopathic male infertility, development of diagnosis and treatment method of male infertility based on analyses of spermatogenesis-associated genes is essential. In this study, we found infertility specific protein in human semen and identified polymorphisms associated with male infertility in human haploid germ cell specific genes.

多达15%的夫妇无法怀孕，而男性要为一半的不孕病例负责。虽然医疗技术的进步使一些不孕夫妇有了孩子，但在大多数情况下，不孕的原因尚不清楚。许多基因只在睾丸中表达，尤其是在睾丸生殖细胞中。我们有理由认为，在各种器官的体细胞没有明显异常的情况下，仅在精子发生中表达的基因的功能缺陷可能导致男性不育。因此，为了了解特发性男性不育症，发展基于精子发生相关基因分析的男性不育症诊断和治疗方法是必要的。在这项研究中，我们在人类精液中发现了不育特异性蛋白，并在人类单倍体生殖细胞特异性基因中发现了与男性不育相关的多态性。

项目成果

Brain processing of audiovisual sexual stimuli inducing penile erection: a positron emission tomography study.

• DOI: 10.1016/j.juro.2006.03.032
• 发表时间: 2006-08
• 期刊: The Journal of urology
• 作者: A. Tsujimura;Y. Miyagawa;K. Fujita;Y. Matsuoka;Tohru Takahashi;T. Takao;K. Matsumiya;Y. Osaki;M. Takasawa;N. Oku;J. Hatazawa;Shigeo Kaneko;A. Okuyama

Progress of ED research and practice in Asia

亚洲ED研究与实践进展

• 发表时间: 2007
• 作者: Tsujimura;Akira
• 通讯作者: Akira

Reprod Med Biol

生殖医学生物

• 发表时间: 2007
• 作者: Uchida;H;Maruyama;T;Nagashima;T;Asada;H;Yoshimura;Y;Tanaka H
• 通讯作者: Tanaka H

マウス精子形成遺伝子とヒト男性不妊関連遺伝子、ならびにこれらを用いた診断システム

小鼠精子发生基因、人类男性不育相关基因以及使用它们的诊断系统

• 发表时间: 2007

Production of Functional Spematids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules.

在异位重建的生精小管中用小鼠生殖干细胞生产功能性精母细胞。

• 发表时间: 2007
• 期刊: Biol. Reprod. 76
• 作者: Kita K.;et. al.(他14)
• 通讯作者: et. al.(他14)