Social experience and the establishment of behavioural syndromes - novel insights from crickets into the role of serotonin in aggression, “personality” and depression-like phenomena

社会经验和行为综合症的建立——蟋蟀对血清素在攻击性、人格和抑郁样现象中的作用的新见解

基本信息

项目摘要

Recently it has become recognised that individual animals of the same species, including many invertebrates, show consistent difference in their behaviour (often referred to as animal personality). Little is known, however, how such inter-individual behavioural differences arise. Our recently published and preliminary work on male crickets reveals that social experience plays a decisive role. As in many animals, crickets that win a fight against a conspecific become hyper-aggressive, while those that lose become submissive, but these changes are short lived (20 min and 3 h). However, as in mammals, multiple defeats (chronic social defeat) also lead to longer term suppression of aggression in crickets (>24 h, possibly life-long). Moreover, the winning and losing experiences lead to long-term changes in general motility, exploratory behaviour and the motor response to tactile stimulation. We have already shown in several papers that the hyper-aggressiveness of winners is mediated by the amine octopamine, and that loser depression results from activation of the nitric oxide signalling pathway. We now aim to investigate t https://de.wiktionary.org/wiki/submissiv he role of such neuromodulators in determining long term changes in behaviour resulting from aggressive experience. Preliminary work indicates that chronic social defeat induces long term depression of aggression coupled with depressed exploratory behaviour via the combined action of nitric oxide and serotonin. This is a rare insight into the natural behavioural role of serotonin in aggression, which is currently not understood in invertebrates or mammals. In mammals, including humans, chronic social defeat is a major stressor that induces depression like symptoms, but the underlying proximate mechanisms are unclear. Thus, our work not only has the potential to unveil “personality” in a model invertebrate as a form of experience dependent plasticity mediated by neuromodulators, it may also offer novel insights into the role of serotonin in depression-like phenomena.
最近人们认识到,同一物种的个体动物,包括许多无脊椎动物,在行为上表现出一致的差异(通常称为动物个性)。然而,人们对这种个体间的行为差异是如何产生的知之甚少。我们最近发表的关于雄性蟋蟀的初步研究表明,社会经验起着决定性的作用。和许多动物一样,蟋蟀在与同种蟋蟀的战斗中获胜后会变得非常具有攻击性,而那些失败的蟋蟀会变得顺从,但这些变化都是短暂的(20分钟和3小时)。然而,在哺乳动物中,多次失败(慢性社会失败)也会导致蟋蟀对攻击性的长期抑制(>24小时,可能是终身的)。此外,赢和输的经验会导致一般运动,探索行为和对触觉刺激的运动反应的长期变化。我们已经在几篇论文中表明,胜利者的过度攻击性是由胺章鱼胺介导的,而失败者的抑郁是由一氧化氮信号通路的激活引起的。我们现在的目标是研究这种神经调质在决定由攻击性经历引起的长期行为变化中的作用。https://de.wiktionary.org/wiki/submissiv初步研究表明,慢性社交失败通过一氧化氮和血清素的联合作用诱导长期的攻击性抑郁,再加上抑郁的探索行为。这是对血清素在攻击中的自然行为作用的罕见见解,目前在无脊椎动物或哺乳动物中还不了解。在包括人类在内的哺乳动物中,慢性社会失败是导致抑郁样症状的主要压力源,但潜在的近似机制尚不清楚。因此,我们的工作不仅有可能揭示“人格”在模型无脊椎动物作为一种形式的经验依赖可塑性介导的神经调质,它也可能提供新的见解血清素在抑郁症样现象的作用。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Fight or flee? Lessons from insects on aggression
战斗还是逃跑?
  • DOI:
    10.1515/nf-2017-0040
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stevenson PA;Rillich J
  • 通讯作者:
    Rillich J
Differential modulation of courtship behavior and subsequent aggression by octopamine, dopamine and serotonin in male crickets
章鱼胺、多巴胺和血清素对雄性蟋蟀求偶行为和随后的攻击行为的差异调节
  • DOI:
    10.1016/j.yhbeh.2019.06.006
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Rillich J;Rillich B;Stevenson PA
  • 通讯作者:
    Stevenson PA
Pre-adult aggression and its long-term behavioural consequences in crickets
  • DOI:
    10.1371/journal.pone.0230743
  • 发表时间:
    2020-03-26
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Balsam, Julia S.;Stevenson, Paul A.
  • 通讯作者:
    Stevenson, Paul A.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Professor Dr. Paul Anthony Stevenson其他文献

Professor Dr. Paul Anthony Stevenson的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Professor Dr. Paul Anthony Stevenson', 18)}}的其他基金

Control of aggression by biogenic amines in crickets
生物胺对蟋蟀攻击行为的控制
  • 批准号:
    175437803
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Research Units

相似海外基金

Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance
儿科 HIV/SIV 病毒库建立和维持的免疫决定因素
  • 批准号:
    10701467
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Establishment of a multi-center biobank of patient-specific induced pluripotent stem cells for pediatric sepsis research
建立用于儿童脓毒症研究的患者特异性诱导多能干细胞多中心生物库
  • 批准号:
    10649014
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Establishment Process of Diverse Rice Cultivation Calendars Applying Failure Experience Learning Model for Climate Resilient Crop Production
应用失败经验学习模型进行气候适应性作物生产的多种水稻种植日历的建立过程
  • 批准号:
    23K05463
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Oral microbiome establishment and development of Latinx Children at the US-Mexico border
美墨边境拉丁裔儿童口腔微生物群的建立和发展
  • 批准号:
    10644580
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Establishment of Theoretical and Methodological Foundations for Building a Cycle of Realizing Living Environment/Lifestyle Centered on Dwelling Experience
构建以居住体验为中心的人居环境/生活方式实现循环的理论和方法论基础
  • 批准号:
    23H01583
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Investigating the metabolic effects and de novo establishment of circadian timing differences between brain and liver
研究大脑和肝脏之间昼夜节律差异的代谢影响和从头建立
  • 批准号:
    10464188
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Establishment of Somatic Cell Nuclear Transfer as a Universal Platform for Cloning Marmosets
体细胞核移植作为克隆狨猴通用平台的建立
  • 批准号:
    10510648
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Establishment of Somatic Cell Nuclear Transfer as a Universal Platform for Cloning Marmosets
体细胞核移植作为克隆狨猴通用平台的建立
  • 批准号:
    10682479
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Investigating the metabolic effects and de novo establishment of circadian timing differences between brain and liver
研究大脑和肝脏之间昼夜节律差异的代谢影响和从头建立
  • 批准号:
    10580595
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Molecular Codes for the Establishment of Functionally Segregated Dopaminergic Circuits
建立功能分离的多巴胺能回路的分子密码
  • 批准号:
    10415208
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了