Exome-wide association study on Hashimoto encephalopathy with thyroiditis

桥本脑病与甲状腺炎的全外显子组关联研究

• 批准号: 26670481
• 负责人: Tanaka Masashi
• 金额: $ 2.33万
• 依托单位: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26670481/
• 关键词: 橋本脳症; 慢性甲状腺炎; エクソーム解析; HLA-DRA; 抗N末端α-エノラーゼ; 関連解析; エクソン領域; 機能的多型; アミノ酸置換; 自己免疫疾患; 橋本甲状腺炎; 遺伝子多型

项目成果

A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese

维尔纳综合征基因的错义单核苷酸多态性 V114I 与日本人骨质疏松和股骨骨折的风险相关

• DOI: 10.1007/s00774-014-0636-0
• 发表时间: 2015
• 期刊: Journal of Bone and Mineral Metabolism.
• 作者: Zhou H;Mori S;Tanaka M;Sawabe M;Arai T;Muramatsu M;Mieno MN;Shinkai S;Yamada Y;Miyachi M;Murakami H;Sanada K;Ito H.
• 通讯作者: Ito H.

Polygenic risk for hypertriglyceridemia is attenuated in high-fitness men.

在高健康水平的男性中，高甘油三酯血症的多基因风险会降低。

• DOI: 10.1152/physiolgenomics.00182.2013
• 发表时间: 2014
• 期刊: Physiol Genomics.
• 作者: Tanisawa K;Ito T;Sun XM;Cao ZB;Sakamoto S;Tanaka M;Higuchi M.
• 通讯作者: Higuchi M.

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.

• DOI: 10.1186/s13041-015-0142-x
• 发表时间: 2015-08-20
• 期刊: Molecular brain
• 影响因子: 3.6
• 作者: Nishizawa D;Kasai S;Hasegawa J;Sato N;Yamada H;Tanioka F;Nagashima M;Katoh R;Satoh Y;Tagami M;Ujike H;Ozaki N;Inada T;Iwata N;Sora I;Iyo M;Yamada M;Kondo N;Won MJ;Naruse N;Uehara-Aoyama K;Itokawa M;Ohi K;Hashimoto R;Tanisawa K;Arai T;Mori S;Sawabe M;Naka-Mieno M;Yamada Y;Yamada M;Sato N;Muramatsu M;Tanaka M;Irukayama-Tomobe Y;Saito YC;Sakurai T;Hayashida M;Sugimura H;Ikeda K
• 通讯作者: Ikeda K

Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity

• DOI: 10.1007/s12263-014-0416-4
• 发表时间: 2014-09-01
• 期刊: GENES AND NUTRITION
• 影响因子: 3.5
• 作者: Tanisawa, Kumpei;Ito, Tomoko;Higuchi, Mitsuru
• 通讯作者: Higuchi, Mitsuru

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.

• DOI: 10.1002/ana.24506
• 发表时间: 2015-11
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Yatsuga, Shuichi;Fujita, Yasunori;Ishii, Akiko;Fukumoto, Yoshihiro;Arahata, Hajime;Kakuma, Tatsuyuki;Kojima, Toshio;Ito, Masafumi;Tanaka, Masashi;Saiki, Reo;Koga, Yasutoshi
• 通讯作者: Koga, Yasutoshi