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Developmental studies on soft polyfluoroethylene as maxillofacial prosthesis material

软质聚氟乙烯颌面修复材料的开发研究

基本信息

批准号：
58870095
负责人：
MASUHARA Eiichi
金额：
$ 3.52万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1983
资助国家：
日本
起止时间：
1983 至 1985
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-58870095/
关键词：
Maxillofacial prosthesis material Fluorinated polymer Terpolymer Water sorption 機械的強度

项目摘要

1. Various properties of fluorinated polymer Taking into consideration the chemical stability and water- or oilrepellence of fluorinated compounds, various kinds of acrylic fluorinated monomers were prepared. The monomers were polymerized and fundamental properties of the polymers as prosthesis materials were determined. It was found that specific gravity was increased by the fluorination of polymer, and that refractive index, surface hardness and water sorption were decreased. Further, fluorinated polymer demonstrated smaller amount of protein adsorption on its surface.2. Preparation of soft polyfluoroethyleneSoft fluorinated polymer was prepared by terpolymerization of vinylidene fluoride, trifluorochloroethylene and tetrafluoroethylene. Since the polymer was soluble and possessed excellent mechanical properties, polymer sheet or polymer solution was used to prepare prosthesis materials. Methacrylic unit was incorporated into low molecular weight polyfluoroethylene and it was found that the polyfluoroethylene monomer could easily be polymerized by redox or visible light initiators.3. Application of soft polyfluoroethyleneVarious biological evaluation of the synthesized soft polyfluoroethylene were carried out. They were hemolysis test or cell culture test using silicone rubber as a control, and subcutaneous implantation test for rats. It was ascertained that the polyfluoroethylene did not cause any severe tissue reaction and that the polymer was stable in a body for a long time. The soft polyfluoroethylene was clinically applied to soft denture liner, coating material for tissue conditioner and various prostheses. Based on the results, it was concluded that the soft polyfluoroethylene was a promising material as maxillofacial prosthesis material.

1.含氟聚合物的各种性能考虑到含氟化合物的化学稳定性和拒水拒油性能，合成了不同种类的丙烯酸类含氟单体。对单体进行了聚合，并测定了聚合物作为假体材料的基本性能。结果表明，聚合物的氟化提高了聚合物的比重，降低了折射率、表面硬度和吸水率。此外，含氟聚合物的表面吸附蛋白质的量较少。以偏氟乙烯、三氟氯乙烯和四氟乙烯为原料，采用三元共聚法制备了软聚氟乙烯软氟化聚合物。由于聚合物是可溶的，且具有良好的力学性能，因此通常采用聚合物片状或聚合物溶液来制备假体材料。在低相对分子质量聚氟乙烯中引入甲基丙烯酸单元，发现聚氟乙烯单体可以通过氧化还原或可见光引发剂进行聚合。软聚氟乙烯的应用对合成的软聚氟乙烯进行了各种生物学评价。分别进行溶血试验或以硅橡胶为对照的细胞培养试验和大鼠皮下植入试验。确定聚氟乙烯不会引起任何严重的组织反应，并且聚合物在体内长期稳定。软聚氟乙烯在临床上应用于软性义齿衬里、组织调节剂涂层材料和各种修复体。实验结果表明，软聚氟乙烯是一种很有前途的颌面部修复材料。