3D printing of realistic MRI phantoms to improve MR sequence design and reproducibility: Feasibility study on a model of liver metastasis

3D 打印真实 MRI 模型以改善 MR 序列设计和再现性：肝转移模型的可行性研究

• 批准号: 402193160
• 负责人: Privatdozent Dr. Paul Jahnke
• 金额: --
• 依托单位: Institut für diagnostische und interventionelle Radiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/402193160?language=en
• 关键词: 3D; printing; realistic; MRI; phantoms

Development of MR sequences and quantitative MR parameters requires testing on patient populations. However, availability of patients is limited and patient studies are associated with considerable challenges. Furthermore, inter- and intraindividual variability of patients restricts data comparability and complicates standardization. In this project, we therefore aim to develop a method for 3D printing realistic anthropomorphic MR phantoms of patients with a detailed simulation of signalling properties of patient tissues and pathologies. We will use 3D printed phantoms of patients with metastatic liver disease to optimize and standardize MR sequences, including T1 mapping, over different field strengths and scanner systems. Finally, we will translate the gained knowledge into a patient setting and test the potential of this approach to improve the detection of liver metastases and the standardization of MR measurements. The resulting realistic anthropomorphic MR phantoms will allow uncomplicated access to pathologies, facilitate MR sequence development and improve the standardization of MR imaging sequences over different field strengths and scanner systems. On this basis, this project will result in improved MR techniques and standardized MR parameters for early diagnosis of liver metastases, improving patient therapies and outcome.

磁共振序列和定量磁共振参数的开发需要对患者群体进行测试。然而，患者的可用性有限，患者研究面临相当大的挑战。此外，患者个体间和个体内的可变性限制了数据的可比性，并使标准化复杂化。因此，在这个项目中，我们的目标是开发一种3D打印逼真的拟人化患者MR模型的方法，并详细模拟患者组织和病理的信号特性。我们将使用3D打印的转移性肝病患者的幻影来优化和标准化MR序列，包括T1映射，在不同的场强和扫描仪系统上。最后，我们将把获得的知识转化为患者环境，并测试这种方法的潜力，以提高肝转移的检测和MR测量的标准化。由此产生的逼真的拟人MR幻影将允许简单地访问病理，促进MR序列的开发，并提高不同场强和扫描仪系统上MR成像序列的标准化。在此基础上，本项目将改进MR技术和标准化MR参数，用于肝转移的早期诊断，改善患者的治疗和预后。