Developmental Studies of Eluorescein Video Angiography and New Analysis Software on Retinal Microcirculation

荧光素视频血管造影及新型视网膜微循环分析软件的发展研究

• 批准号: 60870061
• 负责人: MATSUO Nobuhiko
• 金额: $ 11.84万
• 依托单位: Grant-in Aid for Scientific Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60870061/
• 关键词: Fluorescein Angiography; Video; Image Analysis; Dye Dilution; Retinal circulation; Retinal Vein Occulsion; Diabetes; Buenger病; 蛍光眼底テレビ撮影; 螢光眼底テレビ撮影

We developed a system determining retinal mean circulation tiem(MCT).1. Fulorescein video angiography: A superhigh sensitivity TV camera was connected to a fulorescein photograph unit. The fluorescein video antiogram of the ocular fundus was recorded in a bideo tape.2. Image analysis and calculation: The reproduced bideo angiogram was transferred to an image analyzer and densities of large retinal vessels were analyzed. The measured data were regressed to an optimal lognormal distribution function manidesting a dye dilution curve. MCTs of given retinal segements were calculated.3. Reproducibility. Double determination was performed. It was proved that this system had a good reproducibility as a clinical tool measuring retinal circulation.4. Normal valus. MCT in 50 normal eyes was 3.00 +/- 1.26 (mean +/standard deviation). There were no significant differences in retinal circulation time between four major retinal segments.5. Branch Retinal Vein Cclusion (BRVO): In ten fresh BRVO, MCT in the involved area was longer than in the non-involved area. In 22 old BRVO, MCT in the involved area was shorter than in the non-involved area.6. Diabetic Retinopathy: MCT was measured in 38 diabetic eyes. MCT in the simple retinopathy was shorter than in the noermal. MCT in the proliferative retinopathy was longer than in the normal. Furchermore, MCT in the preproliferative retinopathy was longer than in the proliferative retinopathy.7. Buerger disease: MCT of a patient with Berger disease was prolonged in spite of the presence of collateral channels, indicating insufficiency of the retianla circulation.

我们开发了一个系统确定视网膜平均循环时间（MCT）。荧光素视频血管造影：超高灵敏度电视摄像机连接到荧光素摄影单元。荧光素眼底视频造影记录在透明带上.图像分析和计算：将复制的bideo血管造影片转移到图像分析仪，并分析大视网膜血管的密度。将测得的数据回归到一个最佳的对数正态分布函数，以确定染料稀释曲线。计算视网膜节段的MCT.生殖器。进行双重测定。实验证明，该系统具有良好的重复性，可作为临床测量视网膜循环的工具.正常值。50只正常眼的MCT为3.00 ± 1.26（平均值±标准差）。四个主要视网膜节段之间的视网膜循环时间无显著性差异.视网膜分支静脉阻塞（branchretinalveinocclusion，BRVO）：10例新鲜BRVO中，病变区MCT较非病变区长。22例陈旧性BRVO患者病变区MCT短于非病变区.糖尿病视网膜病变：在38只糖尿病眼中测量MCT。单纯性视网膜病变组的MCT较正常对照组短。增殖性视网膜病变组的MCT较正常组延长。Furchermore，增殖前视网膜病变的MCT较增殖性视网膜病变的长. Buerger病：尽管存在侧支循环，但伯杰病患者的MCT仍延长，表明视网膜循环不足。

项目成果

清水 慶一: 日本眼科学会雑誌.

Keiichi Shimizu：日本眼科学会杂志。

小山 鉄郎: 瞳青. 91. 96-103 (1986)

小山哲朗：青瞳 91. 96-103 (1986)

Tetsuro KOYAMA: Microcirculation an Update (International Congress SeriesNO.755) Elsevier Science Publishers Biomedical Division, Amsterdam. 2. 77-78 (1987)

Tetsuro KOYAMA：微循环更新（国际大会系列第 755 号）爱思唯尔科学出版社生物医学部，阿姆斯特丹。

三原 正義: 日本眼科学会雑誌.

三原正芳：日本眼科学会杂志。

Keiichi SHIMIZU: "Measutemtn of Retinal Mean Circulation Time Using Videofulourescein Angiography and Image Analysis System I. Retinal Mean Circulation Time of the Normal Eye Acta Societatis Ophthalmologicae Japonicae" 91. 956-961 (1987)

Keiichi SHIMIZU：“使用视频荧光素血管造影和图像分析系统测量视网膜平均循环时间 I. 正常眼的视网膜平均循环时间 Acta Societas Olookingmologicae Japonicae” 91. 956-961 (1987)