Basic and Clinical Studies on Choroidal Circulation and its Disorders

1.对神经因子和内分泌因子的研究，其中有规律的混沌循环。（1） Nerve factors - Both nor - adrenergic and acetylcholin - esterage positive nerve fibers were distributed around smooth muscle cells of choroidal arterioles of rabbits。Adrenergic nerve endings were also recognized close to choroidal melanocytes of monkeys。Choroidal blood flow increased significantly after cutting the cervical sympathetic nerve in rabbits， and decreased after stimulating it。（2）Prostaglandins-Choroidal blood flow of rabbits increased significantly after administrating a small dose of prostaglandin I-D22- derivative and E-D21-D2。（3） It was suggested that the renin-angiotensin system was involved in choroidal circulation。（4）含糖蛋白（ET）-1的Choroidal blood flow of rabbits decreased significantly after intravenous or intravitreal injection of endothelin （ET）-1。An endothelin A-receptor anatagonist improved choroidal circulatory disorders of rats when ET - 1 participated in the ... More disorder。（5） Choroidal blood flow of rabbits decreased significantly after intravenous adminManagement of specific inhibitor of an endothelium-derived relaxing factor。（6） Choroidal Blood Flow明显地减少了兔子对视网膜层的选择性损伤。Choriocapillaris的结构被认为是由Retinal Pigment Epithelium调节的。来自以上结果，合唱团循环由两种神经和内分泌因素调节，也由合唱团黑色素细胞和视网膜外层调节。另外，似乎也有一种可能性，即混沌循环的自动化。关于使用激光视光镜扫描的印度洋蓝绿色视频血管造影的基本和临床研究。（1）使用扫描激光光学显微镜和图像分析系统的扫描激光测距仪的测量数字。这一数字技术是有用的，可以用来衡量实验动物的合唱容器的测量在医疗治疗后是如何变的。（2） This technique was also useful for the clinical detection of the choroidal circulatory disorder in various fundus diseases， especially the early detection of feeder vessels into subfoveal choroidal neovascularization of age - related macular degeneration。And selective localized laser photocogulation for the feeder vessels were effective to age - related macular degeneration。Less（低）

1. Studies on nerve factors and endothelial factors which regulate choroidal circulation. (1) Nerve factors - Both nor - adrenergic and acetylcholin - esterage positive nerve fibers were distributed around smooth muscle cells of choroidal arterioles of rabbits. Adrenergic nerve endings were also recognized close to choroidal melanocytes of monkeys. Choroidal blood flow increased significantly after cutting the cervical sympathetic nerve in rabbits, and decreased after stimulating it. (2) Prostaglandins - Choroidal blood flow of rabbits increased significantly after administrating a small dose of prostaglandin IィイD22ィエD2 - derivative and EィイD21ィエD2. (3) It was suggested that the renin - angiotensin system was involved in choroidal circulation. (4) Choroidal blood flow of rabbits decreased significantly after intravenous or intravitreal injection of endothelin (ET) - 1. An endothelin A - receptor anatagonist improved choroidal circulatory disorders of rats when ET - 1 participated in the … More disorder.(5) Choroidal blood flow of rabbits decreased significantly after intravenous administration of specific inhibitor of an endothelium - derived relaxing factor. (6) Choroidal blood flow decreased significantly in rabbits with selective damage of the retinal layer. The structure of choriocapillaris was thought to be regulated by the retinal pigment epithelium. From above results, choroidal circulation was regulated by both nerve and endothelial factors, and also by choroidal melanocytes and the retinal outer layer. There also seemed to be a possibility of autoregulation of choroidal circulation.2. Basic and clinical studies on indocyanine green video angiography using the scanning laser ophthalmoloscope. (1) The diameters of choroidal vessels were measured digitally by using the scanning laser ophthalmoscope and image analysis system. This digital technique was useful for measuring how the diameters of choroidal vessels of experimental animals were changed especially after medical treatment. (2) This technique was also useful for the clinical detection of the choroidal circulatory disorder in various fundus diseases, especially the early detection of feeder vessels into subfoveal choroidal neovascularization of age - related macular degeneration. And selective localized laser photocoagulation for the feeder vessels were effective to age - related macular degeneration. Less