Basic and Clinical Studies on Choroidal Circulation and its Disorders

脉络膜循环及其疾病的基础和临床研究

• 批准号: 04404068
• 负责人: MATSUO Nobuhiko
• 金额: $ 16.64万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04404068/
• 关键词: Choroid; Circulatory regulation; Nerve factor; Endothelial factor; Autoregulation; Scanning laser ophthalmoscope; Indocyanine green; Age - related macular degeneration; 脈絡膜循環; 酸素と炭酸ガス; 眼内手術; エンドリセンA受容体拮抗薬; アンジオテンシンII受容体拮抗薬; 走査レーザー検眼鏡; インドシアニ

1. Studies on nerve factors and endothelial factors which regulate choroidal circulation. (1) Nerve factors - Both nor - adrenergic and acetylcholin - esterage positive nerve fibers were distributed around smooth muscle cells of choroidal arterioles of rabbits. Adrenergic nerve endings were also recognized close to choroidal melanocytes of monkeys. Choroidal blood flow increased significantly after cutting the cervical sympathetic nerve in rabbits, and decreased after stimulating it. (2) Prostaglandins - Choroidal blood flow of rabbits increased significantly after administrating a small dose of prostaglandin IィイD22ィエD2 - derivative and EィイD21ィエD2. (3) It was suggested that the renin - angiotensin system was involved in choroidal circulation. (4) Choroidal blood flow of rabbits decreased significantly after intravenous or intravitreal injection of endothelin (ET) - 1. An endothelin A - receptor anatagonist improved choroidal circulatory disorders of rats when ET - 1 participated in the … More disorder.(5) Choroidal blood flow of rabbits decreased significantly after intravenous administration of specific inhibitor of an endothelium - derived relaxing factor. (6) Choroidal blood flow decreased significantly in rabbits with selective damage of the retinal layer. The structure of choriocapillaris was thought to be regulated by the retinal pigment epithelium. From above results, choroidal circulation was regulated by both nerve and endothelial factors, and also by choroidal melanocytes and the retinal outer layer. There also seemed to be a possibility of autoregulation of choroidal circulation.2. Basic and clinical studies on indocyanine green video angiography using the scanning laser ophthalmoloscope. (1) The diameters of choroidal vessels were measured digitally by using the scanning laser ophthalmoscope and image analysis system. This digital technique was useful for measuring how the diameters of choroidal vessels of experimental animals were changed especially after medical treatment. (2) This technique was also useful for the clinical detection of the choroidal circulatory disorder in various fundus diseases, especially the early detection of feeder vessels into subfoveal choroidal neovascularization of age - related macular degeneration. And selective localized laser photocoagulation for the feeder vessels were effective to age - related macular degeneration. Less

1.调节脉络膜循环的神经因子和内皮因子的研究。(1)神经因素：去甲肾上腺素能和乙酰胆碱酯酶阳性神经纤维分布于兔脉络膜小动脉平滑肌细胞周围。肾上腺素能神经末梢也被确认接近猴的脉络膜黑色素细胞。（2）前列腺素-兔脉络膜血流量在给予小剂量前列腺素I受体D22受体D2 -衍生物和E受体D21受体D2后显著增加。(3)提示脉络膜循环中存在着肾素-血管紧张素系统. (4)静脉或玻璃体内注射内皮素（ET）-1后，兔脉络膜血流量明显减少。内皮素A受体拮抗剂可改善ET - 1参与的脉络膜循环障碍。 ...更多信息 disorder. (5)静脉注射内皮源性舒张因子的特异性抑制剂后，兔脉络膜血流量明显减少。(6)选择性视网膜层损伤兔脉络膜血流量明显减少。脉络膜毛细血管的结构被认为是由视网膜色素上皮调节的。从以上结果可以看出，脉络膜循环受神经和内皮因子的共同调控，同时也受脉络膜黑素细胞和视网膜外层的调控。脉络膜循环的自动调节似乎也是可能的。激光扫描眼底镜吲哚菁绿色视频血管造影的基础与临床研究。(1)应用激光扫描检眼镜和图像分析系统对脉络膜血管直径进行数字化测量。这种数字化技术可用于测量实验动物脉络膜血管直径的变化，特别是药物治疗后的变化。(2)该技术也可用于临床检测各种眼底疾病中的脉络膜循环障碍，特别是早期检测年龄相关性黄斑变性的中心凹下脉络膜新生血管的供血血管。选择性局部光凝治疗老年性黄斑变性的效果较好.少

项目成果

喜多嶋修也 栗本清伸 馬場哲也 白神史雄 松尾信彦: "実験的網膜剥離眼に対する脈絡膜組織血流量の変化 第2報慢性期の変化" 第59回日本中部眼科学会. (発表). (1993)

Shuya Kitajima、Kiyonobu Kurimoto、Tetsuya Baba、Fumio Shirakami、Nobuhiko Matsuo：“实验性视网膜脱离眼中脉络膜组织血流的变化。第二次报告：慢性期的变化”第 59 届日本中部眼科学会（演讲）。 ）

栗本清伸: "脈絡膜循環に及ぼすガスの影響第1報酸素の影響" 日本眼科紀要. 46(発表予定). (1995)

Kiyonobu Kurimoto：“气体对脉络膜循环的影响第 1 部分：氧气的影响”日本眼科公报 46（即将出版）。

森靖弘: "N^Gモノメチル-L-アルギニンの脈絡膜組織血流量への影響第1報N^G-モノメチル-L-アルギニンの全身投与の影響" 日本眼科紀要. 45. 1163-1167 (1994)

Yasuhiro Mori：“N^G 单甲基-L-精氨酸对脉络膜组织血流的影响，第 1 部分。N^G-单甲基-L-精氨酸全身给药的影响”日本眼科通报 45. 1163-1167 (1994)。

Shiraga, Fumio: "Identification of feeder vessels in subfoveal choroidal neovascularization"Rinsho Ganka (Jpn. J. Ophthalmol.). 49. 63-71 (1995)

Shiraga，Fumio：“在中心凹下脉络膜新生血管形成中的供给血管的识别”Rinsho Ganka（Jpn. J. Ophthalmol.）。

岡田 大造,松尾 信彦,大島 浩一,森 繁広: "エンドセリン1の脈絡膜組織血流量への影響" 第58回日本中部眼科学会. (1992)

Daizo Okada、Nobuhiko Matsuo、Koichi Oshima、Shigehiro Mori：“内皮素 1 对脉络膜组织血流的影响”第 58 届日本中部眼科学会（1992 年）。