Synthesis and Evaluation of Photosensitizeing Dyes for Photodynamic Diagnosis and Therapy.

用于光动力诊断和治疗的光敏染料的合成和评价。

• 批准号: 60890007
• 负责人: OGOSHI Hisanobu
• 金额: $ 12.35万
• 依托单位: Technological University of Nagaoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60890007/
• 关键词: EARLY CANCER; PHOTODYNAMIC DIAGNOSIS AND THERAPY; PHOTOSENSTITIZIND DYES; パルス色素レーザー; 光応答性色素; がんの診断と治療; レーザー医学; 含フッ素ポルフィリン

Varous Kinds of Porphyrin and cholorophyll derivatives have been synthesized from naturally occuring protoporphyrins and chloorphyll and stepwise synthetic methods to provide new photosensitizing dyes in photodynamic diagnosis and therapy in early cancer. Specific accumu- lation of dyes in cancer cell depends upon their molecular structure; highly symmetric allocation of polar substituents shows no effective accumulation of dye in cancer cell; localized substitutuion of both polar and non-polar groups is essential to exert diagnosis. Mechanism of interaction between dye and cancer cell has been elucidated; dye molecule injected in blood binds membrene of cancer cell, penetrates the membrene, contact with the membrene of mitochondria. Fluorine containning dyes seem to be promisible chemical probe to three dimensional analysis of deep cancer with nuclear magnetic resonance technique.

以天然存在的原卟啉和叶绿素为原料，采用分步合成的方法合成了各种卟啉和叶绿素衍生物，为早期癌症的光动力学诊断和治疗提供了新的光敏染料。染料在癌细胞中的特异性积累取决于其分子结构；极性取代基的高度对称分配表明癌细胞中没有有效的染料积累；极性和非极性基团的局部替换对诊断至关重要。染料与癌细胞相互作用的机制已被阐明；注入血液中的染料分子与癌细胞膜结合，穿透细胞膜，与线粒体膜接触。含氟染料是核磁共振技术用于深部肿瘤三维分析的理想化学探针。

项目成果

山下幹雄: 応用物理. 56. 235-237 (1987)

山下干雄：应用物理学。56。235-237（1987）

日本レーザー医学会誌. 5-3. (1985)

日本激光医学会杂志 5-3 (1985)。

H.Ososhi;H.Mizushima;H.Toi;and Y.Aoyama: J.Organic Chemistry. 51. 2366-2368 (1986)

H.Ososhi；H.Mizushima；H.​​Toi；和 Y.Aoyama：J.有机化学。

K.Aizawa;H.Kato;N.Ohtani;and Y.Hayata: Photochemistry and Photobiology. 46. 789-793 (1987)

K.Aizawa；H.Kato；N.Ohtani；和 Y.Hayata：光化学和光生物学。

H.Ogoshi, K. Saita, T. Watanabe, H. Toi, and Y. Ayoyama: "Synthesis of New Chiral Porphyrins." Tetrahedron Letters.27. 6365-6368 (1986)

H.Ogoshi、K. Saita、T. Watanabe、H. Toi 和 Y. Ayoyama：“新手性卟啉的合成”。