Effect on Biological Tissues in Photodynamic Diagnosis and Therapy using Plastic Optical Fiber Amplifier

塑料光纤放大器在光动力诊断和治疗中对生物组织的影响

• 批准号: 07555019
• 负责人: SASAKI Keisuke
• 金额: $ 8.26万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07555019/
• 关键词: Polymer optical fiber; Photodynamic treatment; Dye laser; Photosensitive material; Oxygene radical; Luminol reaction; Cancer therapy; Cancer Diagnosis

Polymer optical fiber amplifier (POFA) is proposed and evaluated and its application is investigated.Experimentally and theoretically, the basic performance of POFA is studied. It was evaluated experimentally and by the theoretical model that an order of kilo watt of amplified signal and ASE was obtained by an order of hundred millimeter length-POFA at around 600 nm-wavelength. Especially, ASE-POFA requires pumping source only. Thus, the ASE-POFA is promising to be an easy-handling visible optical source. As one of the application of the POFA,optical source for photodynamic diagnosis (PDD) and photodynamic therapy (PDT) is proposed. Generation of the fluorescence an active oxygen from the photosensitizer excited by the POFA is detected and possibility for the PDD and PDT by the POFA is discussed. In addition, microscopic mechanism of the PDT was evaluated experimentally. Cacer killing effect and phenomena of vascular shut down (VSD) was observed for the first time with the Zinc-photosensitizer.

提出并评价了聚合物光纤放大器（POFA），研究了它的应用，从实验和理论上研究了POFA的基本性能。实验和理论模型表明，在600 nm波长附近，用一个百毫米量级的POFA可以获得千瓦量级的放大信号和ASE。特别地，ASE-POFA仅需要泵浦源。因此，ASE-POFA有望成为一种易于操作的可见光光源。作为POFA的应用之一，提出了用于光动力学诊断（PDD）和光动力学治疗（PDT）的光源。研究了POFA对光敏剂活性氧荧光的激发，探讨了POFA用于光动力学诊断和光动力学治疗的可能性。此外，还对PDT的微观机理进行了实验研究。首次观察到锌光敏剂的杀癌作用和血管关闭现象。

项目成果

T.Yamamoto,K.Fujii,A.Tagaya,E.Nihei,Y.Koike & K.Sasaki: "High-power polymer optical fiber amplifier" Electronics and Communications in Japan. 78. 36-44 (1995)

T.山本、K.Fujii、A.Tagaya、E.Nihei、Y.Koike

南谷晴之 山本 剛 飯野 徹 小池康博 佐々木敬介: "診断用光感受性物質への色素ドープ プラスチック光ファイバーの応用の可能性" 応用物理. 65. 36-40 (1996)

Haruyuki Minamiya、Tsuyoshi Yamamoto、Toru Iino、Yasuhiro Koike 和 Keisuke Sasaki：“染料掺杂塑料光纤应用于诊断光敏剂的可能性”应用物理 65. 36-40 (1996)。

T.Yamamoto, K.Fujii, E.Nihei, Y.Koike, K.Sasaki: "High-power polymer optical fiber amplifier" Trans.IECIE. Vol.J78-C-I,No.6. 282-288 (1995)

T.Yamamoto、K.Fujii、E.Nihei、Y.Koike、K.Sasaki：“高功率聚合物光纤放大器”Trans.IECIE。

Yamamoto, T.Iino, Koike, K.Sasaki: "Dye-doped plastic optical fiber for visible optical source laser" Proc.16^<th> Jap.Soc.Laser Med.155-160 (1995)

Yamamoto, T.Iino, Koike, K.Sasaki：“用于可见光源激光的染料掺杂塑料光纤”Proc.16^<th> Jap.Soc.Laser Med.155-160 (1995)

山本剛,飯野徹,小池康博,佐々木敬介,南谷晴之: "可視光源レーザ用色素添加プラスチック光ファイバ" 日本レーザー医学会第16回大会論文集. 155-160 (1995)

Tsuyoshi Yamamoto、Toru Iino、Yasuhiro Koike、Keisuke Sasaki、Haruyuki Minamitani：“用于可见光源激光器的有色塑料光纤”日本激光医学学会第 16 届年会记录 155-160 (1995)。