Effect on Biological Tissues in Photodynamic Diagnosis and Therapy using Plastic Optical Fiber Amplifier

提出并评价了聚合物光纤放大器(POFA)，并对其应用进行了研究，从实验和理论上研究了POFA的基本性能。实验和理论模型均表明，在600 nm波长附近，100毫米长的POFA获得了千瓦量级的放大信号和ASE。特别是，ASE-POFA只需要泵浦源。因此，ASE-POFA有望成为一种易于操作的可见光光源。作为POFA的应用之一，提出了用于光动力诊断(PDD)和光动力治疗(PDT)的光源。检测到POFA激发的光敏剂产生了活性氧的荧光，并讨论了POFA用于PDD和PDT的可能性。此外，还对光动力学的微观机理进行了实验评价。本文首次观察了锌光敏剂对肿瘤的杀伤作用和血管关闭现象。

Polymer optical fiber amplifier (POFA) is proposed and evaluated and its application is investigated.Experimentally and theoretically, the basic performance of POFA is studied. It was evaluated experimentally and by the theoretical model that an order of kilo watt of amplified signal and ASE was obtained by an order of hundred millimeter length-POFA at around 600 nm-wavelength. Especially, ASE-POFA requires pumping source only. Thus, the ASE-POFA is promising to be an easy-handling visible optical source. As one of the application of the POFA,optical source for photodynamic diagnosis (PDD) and photodynamic therapy (PDT) is proposed. Generation of the fluorescence an active oxygen from the photosensitizer excited by the POFA is detected and possibility for the PDD and PDT by the POFA is discussed. In addition, microscopic mechanism of the PDT was evaluated experimentally. Cacer killing effect and phenomena of vascular shut down (VSD) was observed for the first time with the Zinc-photosensitizer.