Development of Induced Fye-movement Examination System

由于眼动的控制与中枢神经系统的功能密切相关，自本世纪初以来，人们做了大量的工作，主要是利用机械运动目标来诱发眼动。其中，眼球对目标运动的扫视运动是诊断脑干功能的重要指标之一。然而，对于这种测量，患者预测运动的能力有时会干扰精确的测量，我们用周期性或规则信号驱动目标。为了避免这种不准确的测量，我们采用了M阶控制的运动目标。所用的刺激系统由凹形LED阵列面板（4 × 128）、M序列控制器和眼电图（EOG）仪组成。刺激模式在Z 80微处理器中生成。每个备选位置（左侧或右侧）的目标持续时间由M序列确定。为了产生伪随机二进制序列，在软件中编程一个8位移位寄存器序列和反馈逻辑，并获得周期为255的M序列，然后对通过EOG方法测量的眼睛的响应进行计算机分析（ISYC-100，带有计算机UX-300 PII和个人计算机PC 98）。对正常人和患眼的目标运动和眼动之间的相关函数进行了评估。本研究建立的多变量分析方法，已应用于与眼球运动密切相关的眼睑运动障碍的评价，以及其它生物信息处理的实例，如FCM数据分析。

Since the control of eye movement is closely related to the central nervous function, extensive work has been done since the early part of this century, mostly using mechanical moving targets to evoke the eye movement. Among all, saccadic eye movement in response to the target movement is one of the most significant items to be used for diagnosis of the brain-stem functions. However for this measurement, the patient's ability to predict movement sometimes disturbs the exact measurement, whin we drive the target with periodical or regulas signals. In order to avoid this inaccuracy involved in the measurement, we applies an M-siqunce-controlled moving target. The stimulation system we used consisted of a concave LED array panel (4x128), M-sequnce controller ans the electrooculogram(EOG) apparatus. The stimulation patterns are generated in a Z80 microprocessor. The target duration at each alternative position (lest or right) is determined by the M-sequence. For the generation of the pseudorandom hinary sequence, an 8-bit shift register sequence and feedback logic are programmed in the software and the M-sequence of the periodicity 255 is obtained.The response of the eye, measured through the EOG method, is then subjected to computer analysis (ISYC-100 with a computer UX-300FII and a personal computer PC98). The mutual correlation functions between the target movement and the eye movement were evalusted for a normal subjects and for affected subjects. The difference of the wave from is analized to yield Fishers's disctiminant function; giving good separation of the abnormal group from the normal.The multivariste analysis procedures developed in this research were applied to the evaluation of palpebral movement disorders which have close relations to the eye movements, and to other examples of biological information processings such an analysis of FCM data.