Study of Glass Fiber Composite Materials as Biomaterial

将CaO-P_2 O_5SiO_2-Al_2O_3（CPSA）玻璃纤维与丙烯酸树脂（PMMA）复合，制备了一种生物医用玻璃纤维复合材料（CPSA复合材料）。对CPSA复合材料的生物学和力学性能进行了研究。1）细胞培养试验和骨组织观察结果表明，CPSA复合材料具有良好的生物相容性; 2）对CPSA复合材料进行了弯曲、拉伸、拉伸、压缩和剪切表明该复合材料的弹性模量相当于或略高于人皮质骨的约3倍，证明了作为人工骨的生物材料的良好的机械性能。3）发现CPSA复合物在体内和体外测试中具有50%和75%的强度留存率。由于体内和体外强度保持率是相互关联的，因此体外试验获得的数据可用于筛选试验，如开发新的CPSA复合材料。4）作为CPSA复合材料的应用途径，实验制备了一种新的骨合成材料--CPSA骨合成植入物。为设计由该材料制成的钩和板的组合建立了基础数据。该产品用于成年犬股骨内固定，结果正在随访中。

A glass fiber composite for use as biomaterial (CPSA composite) was experimentally produced by cobbining Cao-P_2O_5SiO_2-Al_2O_3 (CPSA) glass fibers and acrylic resin (PMMA). Biological and mechanical properties of the CPSA composite were examined. Furthermore, a new osteosynthetic material, CPSA osteosynthetic implant, was produced and its potential applications were investigated.1) The results of cell culture tests and observation of osseous tissues suggest biocompatibility of the CPSA composite.2) Various mechanical tests of the CPSA composite with respect to bending, tension, compression and shearing showed that the composite is about 3 times stronger ated its elastic modulus equivalent to or slightly higher than human cortical bone, demonstrating favorable mechanical properties as a biomaterial for artificial bone.3) The CPSA composite was found to have a strength retention rate of 50% in in vivo and 75% in in vitro tests. Since the strength retention rates in vivo and in vitro were interrelated, the data obtained by in vitro tests can be applied to screening tests for attempts such as development of new CPSA composites.4) As an approach to application of the CPSA composite, a new osteosynthetic material, CPSA osteosynthetic implant, was experimentally produced. Basic data were established for designing a combination of hooks and plates made of the material. The product was used in internal fixation of the femurs of adult dogs, and the results are being followed up.