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Study of Glass Fiber Composite Materials as Biomaterial

玻璃纤维复合材料作为生物材料的研究

基本信息

批准号：
63870062
负责人：
KUROKI Yoshikatsu
金额：
$ 6.34万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

A glass fiber composite for use as biomaterial (CPSA composite) was experimentally produced by cobbining Cao-P_2O_5SiO_2-Al_2O_3 (CPSA) glass fibers and acrylic resin (PMMA). Biological and mechanical properties of the CPSA composite were examined. Furthermore, a new osteosynthetic material, CPSA osteosynthetic implant, was produced and its potential applications were investigated.1) The results of cell culture tests and observation of osseous tissues suggest biocompatibility of the CPSA composite.2) Various mechanical tests of the CPSA composite with respect to bending, tension, compression and shearing showed that the composite is about 3 times stronger ated its elastic modulus equivalent to or slightly higher than human cortical bone, demonstrating favorable mechanical properties as a biomaterial for artificial bone.3) The CPSA composite was found to have a strength retention rate of 50% in in vivo and 75% in in vitro tests. Since the strength retention rates in vivo and in vitro were interrelated, the data obtained by in vitro tests can be applied to screening tests for attempts such as development of new CPSA composites.4) As an approach to application of the CPSA composite, a new osteosynthetic material, CPSA osteosynthetic implant, was experimentally produced. Basic data were established for designing a combination of hooks and plates made of the material. The product was used in internal fixation of the femurs of adult dogs, and the results are being followed up.

将CaO-P_2O_5SiO_2-Al_2O_3(CPSA)玻璃纤维与丙烯酸树脂(PMMA)进行复合，实验制备了一种用于生物材料的玻璃纤维复合材料(CPSA复合材料)。对CPSA复合材料的生物力学性能进行了测试。1)细胞培养和骨组织观察结果表明CPSA复合材料具有良好的生物相容性。2)CPSA复合材料的弯曲、拉伸、压缩和剪切等多种力学性能测试表明，该复合材料的弹性模量约为人类皮质骨的3倍，表现出良好的力学性能，可作为人工骨的生物材料。3)CPSA复合材料在体内和体外的强度保留率分别为50%和75%。由于体内和体外的强度保持率是相互关联的，体外试验获得的数据可以用于筛选试验，如开发新的CPSA复合材料。4)作为CPSA复合材料应用的一种途径，实验制备了一种新的骨合成材料CPSA骨合成植入物。为设计由该材料制成的钩和板组合建立了基础数据。该产品用于成年犬股骨内固定，结果正在追踪中。