Development of an apparatus for measuring peripheral circulatory function using a photo-sensor

为了研制一种利用光传感器测量外周循环功能的装置，我们进行了基础实验，然后我们应用该装置对使用振动工具的工人的外周循环功能进行了评估。用发光二极管产生与Hb、HbO_2和总Hb的吸光度有关的光，用光电二极管检测透射光和反射光，这种新装置使我们能够观察外周循环的几个指标。结果表明：（1）两种光路无创测量动脉血氧饱和度，其中一种光路的Hb和HbO_2的比值基本相等，另一种光路的Hb和HbO_2的比值相差较大。2)通过测量袖带压迫时透射光强度的变化，并与总血红蛋白（Hb）的变化相关联，来测量指动脉收缩压和平均压力。与此同时， 关于我们 计算由平均压力下的血管体积标准化的血管体积比，并且它使我们能够定量地评估作为粘弹性性质的压力-体积关系。3)通过袖带压力与透射光强度变化之间的关系来评估外周动脉在压力-容积关系中的非线性模式。4)通过与总血红蛋白相关的两种透射光监测全血量。5)临床应用表明，该仪器对周围循环障碍的早期诊断和雷诺现象等周围循环障碍的分期有一定的帮助。通过该装置测量的外周循环功能和组织血流量的几项指标，研究噪音和寒冷以及这些因素对外周循环功能的综合影响。少

In order to develop an apparatus for measuring peripheral circulatory function using a photo-sensor, we have performed fundamental experiments, and then we have applied this apparatus for assessment of peripheral circulatory function of workers using vibrating tools. Using luminous diodes for generating the light concerning the absorbance of Hb, HbO_2 and total Hb and a photo-diode for detecting the transmitted light and the reflected light, this new apparatus enabled us to observe several indices of peripheral circulation. The results obtained in this study were as follows: 1) The arterial oxygen saturation was measured noninvasively through the two light, in one of which the absorbances of Hb and HbO_2 were almost equal and in other the absorbances of Hb and HbO_2 were most different. 2) Systolic and mean pressure of digital arteries was measured through the intensity changes of transmitted light, which was associated with total Hb, in compression induced by a cuff. At the same time, … More the vascular volume ratio standardized by the vascular volume at the mean pressure was calculated, and it enabled us to assess quantitatively the pressure-volume relationship as a viscoelastic property. 3) The non-linear pattern of peripheral arteries in the pressure-volume relationship was assessed through the relationship between the cuff pressure and the intensity changes of the transmitted light. 4) The whole blood volume was monitored through the two kinds of transmitted light which were associated with total Hb. 5) Clinical application indicated that this apparatus was useful for the early diagnosis of peripheral circulatory disturbance and for the classification of the stages in the peripheral circulatory disorders of the subjects who complained the symptoms such as Raynaud's phenomenon.We have a plan to observe and assess synthetically the effects of vibration, noise and coldness and the combined effects of these factors on the peripheral circulatory function through the several indices of peripheral circulatory function measured by this apparatus and tissue blood flow. Less