Synthesis of C-Nucleosides Related Oxetanocin

点击翻译按钮获取中文摘要

In order to develop the chemistry of heterocyclic compounds having antiviral activities, synthesis of nucleosides relating to oxetanocin was investigated. 1) Ring-Closure to Pyrrolopyrimidines New methods for the synthesis of pyrrolo[2,3-d]pyrimidine and pyrrolo[3,2- d]pyrimidine derivatives was established as a basic investigation. 2) Synthesis of Uracil-Type C-Nucleoside Starting from 5-bromo-2,4-bis(benzyloxy)pyrimidine, the synthesis of the 5-pyrimidinyloxetanose was accomplished as shown below. 3) Synthesis of Deazapurine-Type Nucleosides On the basis of the results described in Section 1, the following acyclonucleosides was synthesized.