Synthesis of C-Nucleosides Related Oxetanocin

为了发展具有抗病毒活性的杂环化合物的化学，研究了与氧杂环霉素相关的核苷的合成。1)吡咯并嘧啶类化合物的闭环研究作为基础研究，建立了吡咯并[2，3-d]嘧啶和吡咯并[3，2-d]嘧啶类化合物的合成新方法。2)尿嘧啶型C-核苷的合成从5-溴-2，4-双（苄氧基）嘧啶开始，如下所示完成5-嘧啶基氧杂环丁烷糖的合成。3)脱氮嘌呤型核苷的合成基于第1部分中描述的结果，合成了以下无环嘌呤核苷。

In order to develop the chemistry of heterocyclic compounds having antiviral activities, synthesis of nucleosides relating to oxetanocin was investigated. 1) Ring-Closure to Pyrrolopyrimidines New methods for the synthesis of pyrrolo[2,3-d]pyrimidine and pyrrolo[3,2- d]pyrimidine derivatives was established as a basic investigation. 2) Synthesis of Uracil-Type C-Nucleoside Starting from 5-bromo-2,4-bis(benzyloxy)pyrimidine, the synthesis of the 5-pyrimidinyloxetanose was accomplished as shown below. 3) Synthesis of Deazapurine-Type Nucleosides On the basis of the results described in Section 1, the following acyclonucleosides was synthesized.