Mechanism of transmission of calcium waves by glial cells

神经胶质细胞传递钙波的机制

• 批准号: DP0665689
• 负责人: Prof Maxwell Bennett
• 金额: $ 18.28万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-03-02 至 2008-11-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0665689
• 关键词: Mechanism; transmission; calcium; waves; glial

This research concerns determining the fundamental properties of cells that occupy about 70% of the brain, the glial cells. Two very important discoveries on glial cells have recently been made, namely that they can convey information in the form of patterns of waves and that they possess molecules on their surface membranes that have been implicated in psychotic disorders. One such molecule is called the D2 receptor and its malfunctioning has been implicated in schizophrenia. Our research will determine the way in which information is propagated in the glial system of the brain and also illuminate the function of several of the molecules found on the surface of the glial cells.

这项研究涉及确定占据大脑约70%的细胞的基本特性，即神经胶质细胞。神经胶质细胞最近有两个非常重要的发现，即它们可以以波的形式传递信息，并且它们的表面膜上具有与精神病有关的分子。其中一种分子被称为D2受体，它的功能障碍与精神分裂症有关。我们的研究将确定信息在大脑神经胶质系统中传播的方式，并阐明神经胶质细胞表面上发现的几种分子的功能。