Neuron-microglia signalling mechanisms

神经元-小胶质细胞信号传导机制

• 批准号: DP0879503
• 负责人: Prof Maxwell Bennett
• 金额: $ 22.91万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-18 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879503
• 关键词: Neuron; microglia; signalling; mechanisms

This research concerns determining the fundamental mechanisms by which one of the principal non-neuronal cells in the brain , the microglial cell, interacts with neurons to change their properties. The correct functioning of neural networks is necessary for our normal behaviour. Such networks can be disrupted and indeed destroyed by the release of inflammatory molecules from microglial cells. In this work the way in which anti-inflammatory molecules are released from the microglia will be elucidated, thus providing insight into how to prevent the destructive actions of the inflammatory molecules on the nervous system.

这项研究涉及确定大脑中主要的非神经元细胞之一小胶质细胞与神经元相互作用以改变其特性的基本机制。神经网络的正确运作对我们的正常行为是必要的。这种网络可以被小胶质细胞释放的炎症分子破坏。在这项工作中，抗炎分子从小胶质细胞中释放的方式将被阐明，从而为如何防止炎症分子对神经系统的破坏性作用提供见解。