Neuron-microglia signalling mechanisms

点击翻译按钮获取中文摘要

This research concerns determining the fundamental mechanisms by which one of the principal non-neuronal cells in the brain , the microglial cell, interacts with neurons to change their properties. The correct functioning of neural networks is necessary for our normal behaviour. Such networks can be disrupted and indeed destroyed by the release of inflammatory molecules from microglial cells. In this work the way in which anti-inflammatory molecules are released from the microglia will be elucidated, thus providing insight into how to prevent the destructive actions of the inflammatory molecules on the nervous system.