Calcium Signalling and Sequestration at Vertebrate Motor-Nerve Terminals

脊椎动物运动神经末梢的钙信号传导和隔离

• 批准号: DP0345946
• 负责人: Prof Maxwell Bennett
• 金额: $ 14.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-09 至 2006-01-08
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345946
• 关键词: Calcium; Signalling; Sequestration; Vertebrate; Motor

A fundamental process at Synapses is the release of transmitter from nerve terminals due to the initiation of calcium signalling in the temrinals by impulses. This calcium signalling must be terminated by sequestering processes. The aim of this project is to identify these processes in a vertebrate motor-nerve terminal and to determine the means by which calcium signals the changes in efficacy of transmitter release during trains of impulses. This work will give a complete description of calcium signalling in a vertebrate nerve terminal and provide the basis for ameliorating failures in transmission from nerve to muscle.

突触的一个基本过程是从神经末梢释放递质，这是由于脉冲在末梢启动钙信号。这种钙信号必须通过隔离过程终止。这个项目的目的是在脊椎动物运动神经末梢中识别这些过程，并确定钙信号在脉冲序列中释放递质效率变化的方法。这项工作将对脊椎动物神经末梢钙信号的完整描述，并为改善从神经到肌肉的传递失败提供基础。