A common and potentially prebiotic activating agent for phosphorylation of nucleosides and oligomerization of nucleotides and amino acids

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The proposed cyanogen chloride induced pathway for the synthesis of RNA and peptides includes: 1. phosphorylation of nucleosides to nucleotides; 2. activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization;3. activation of amino acids to peptides and deprotection. This year, the feasibility of cyanogen chloride activated polymerization of amino acids in the solid-phase peptide synthesis has been demonstrated. We also observed that activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization and amino acids polymerization can occur in a one-pot synthesis using cyanogen chloride as a common activating agent.