A common and potentially prebiotic activating agent for phosphorylation of nucleosides and oligomerization of nucleotides and amino acids

一种常见且潜在的益生元活化剂，用于核苷磷酸化以及核苷酸和氨基酸寡聚化

• 批准号: 21K14029
• 负责人: 蟻 瑞欽
• 金额: $ 1.83万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K14029/
• 关键词: amino acids; activating chemistry; peptide synthesis; RNA polymerization; solid-phase synthesis; activation chemistry; phosphorylation; polymerization

The proposed cyanogen chloride induced pathway for the synthesis of RNA and peptides includes: 1. phosphorylation of nucleosides to nucleotides; 2. activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization;3. activation of amino acids to peptides and deprotection. This year, the feasibility of cyanogen chloride activated polymerization of amino acids in the solid-phase peptide synthesis has been demonstrated. We also observed that activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization and amino acids polymerization can occur in a one-pot synthesis using cyanogen chloride as a common activating agent.

提出的氯氰诱导RNA和多肽合成途径包括：1。核苷磷酸化为核苷酸；2. 2 .将核苷酸活化为其5 ' -磷咪唑进行RNA聚合；氨基酸对肽的激活和去保护。今年，氯化氰激活聚合氨基酸在固相肽合成的可行性已被证明。我们还观察到，在使用氯化氰作为常见活化剂的一锅合成中，核苷酸对其5 ' -磷咪唑的激活可以发生RNA聚合和氨基酸聚合。

项目成果

Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying

通过干燥交替共合成乙二醇核酸 (GNA) 单体与二羧酸

• DOI: 10.1039/d2cc06818d
• 发表时间: 2023
• 期刊: Chemical Communications
• 影响因子: 4.9
• 作者: Yi Ruiqin;Jia Tony Z;Meringer Markus;Marshall Luke K.;Chen Chen;McGlynn Shawn E;Fahrenbach Albert C.;Cleaves II H. James
• 通讯作者: Cleaves II H. James

The Effects of Dehydration Temperature and Monomer Chirality on Primitive Polyester Synthesis and Microdroplet Assembly

• DOI: 10.1002/macp.202200235
• 发表时间: 2022-09-04
• 期刊: MACROMOLECULAR CHEMISTRY AND PHYSICS
• 影响因子: 2.5
• 作者: Afrin, Rehana;Chen, Chen;Jia, Tony Z.
• 通讯作者: Jia, Tony Z.