カルノシンの骨格筋再生における生理的役割の解明、および応用

今年，我们进一步进行了实验，以确定肌肽调节剂维生素B6是否对肌肉再生有任何影响。我们发现，与维生素B6推荐水平饲粮（7 mg/kg饲粮）相比，缺乏维生素B6 （1 mg PN* HCl/kg饲粮）和补充维生素B6 （35 mg/kg饲粮）的饲粮显著降低了骨骼肌肌肽水平。接下来，我们发现维生素B6缺乏（1 mg/kg日粮）会损害肌肉再生，表现为再生肌肉量和肌纤维大小低于推荐的维生素B6水平（7 mg/kg日粮）。令人惊讶的是，高剂量的维生素B6（35毫克/公斤饮食）也会恶化肌肉再生，这与我们的预期相反。综上所述，研究结果表明，适当摄入维生素B6和较高水平的肌肽对于确保肌肉再生的正常过程非常重要。PN:盐酸吡哆醇

In this year, we further conducted experiments to determine if a carnosine regulator, vitamin B6, has any effects on muscle regeneration. We found that vitamin B6 deficient (1 mg PN* HCl/kg diet) and supplemented (35 mg/kg diet) diets significantly decreased carnosine levels in skeletal muscles, as compared to vitamin B6 recommended level diet (7 mg/kg diet). Next, we found that vitamin B6 deficiency (1 mg/kg diet) impaired muscle regeneration, reflecting by lower regenerating muscle mass and smaller myofiber size than the recommended vitamin B6 level (7 mg/kg diet) diet. Surprisingly, a high dose of vitamin B6 (35 mg/kg diet) also worsened muscle regeneration, which was against our expectation. Taken together the results suggest that the proper intake levels of vitamin B6 and higher levels of muscle carnosine are important to ensure the proper process of muscle regeneration. PN:Pyridoxine Hydrochloride