Transposable elements shape the evolution of mammalian innate immunity against pathogens

转座因子塑造哺乳动物针对病原体的先天免疫的进化

• 批准号: 21K15066
• 负责人: CHEN Xun
• 金额: $ 3万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K15066/
• 关键词: pathogen-specific; transposable elements; immune cells; transcriptome; evolution; Transposable element; Immune cells; Evolution; Macrophages; Immunology; Comparative epigenomics

We have identified transposable elements (TEs) that are induced by salmonella but not by influenza virus infection in human macrophages last year. We further collected available RNA-seq datasets in immune cells following different pathogen infection separately.This year, We further identified 34 TE families that are highly activated following ebolavirus infection and 43 TE families are activated following influenza infection. They were consistently highly activated in multiple immune cells compared to other pathogens. We also found that these pathogen-specific families are mostly integrated before primates during evolution.

去年，我们已经在人类巨噬细胞中鉴定出由saltamine诱导而非由流感病毒感染诱导的转座因子（TE）。我们进一步收集了不同病原体感染后免疫细胞中可用的RNA-seq数据集。今年，我们进一步鉴定了34个在埃博拉病毒感染后高度激活的TE家族和43个在流感病毒感染后激活的TE家族。与其他病原体相比，它们在多种免疫细胞中始终高度活化。我们还发现，这些病原体特异性的家庭大多是在灵长类动物之前整合在进化过程中。

项目成果

Transposable elements contribute to epigenetic changes in the human response to influenza infection

转座因子导致人类对流感感染反应的表观遗传变化

• 发表时间: 2021
• 作者: Xun Chen