Transposable elements shape the evolution of mammalian innate immunity against pathogens

去年，我们在人巨噬细胞中发现了由沙门氏菌而不是流感病毒感染诱导的转座因子（TEs）。我们进一步收集了不同病原体感染后免疫细胞的RNA-seq数据集。今年，我们进一步确定了34个TE家族在埃博拉病毒感染后高度激活，43个TE家族在流感感染后被激活。与其他病原体相比，它们在多个免疫细胞中始终高度激活。我们还发现，在进化过程中，这些病原体特异性家族大多在灵长类动物之前整合。

We have identified transposable elements (TEs) that are induced by salmonella but not by influenza virus infection in human macrophages last year. We further collected available RNA-seq datasets in immune cells following different pathogen infection separately.This year, We further identified 34 TE families that are highly activated following ebolavirus infection and 43 TE families are activated following influenza infection. They were consistently highly activated in multiple immune cells compared to other pathogens. We also found that these pathogen-specific families are mostly integrated before primates during evolution.