Transposable elements shape the evolution of mammalian innate immunity against pathogens

去年，我们已经在人类巨噬细胞中鉴定出由saltamine诱导而非由流感病毒感染诱导的转座因子（TE）。我们进一步收集了不同病原体感染后免疫细胞中可用的RNA-seq数据集。今年，我们进一步鉴定了34个在埃博拉病毒感染后高度激活的TE家族和43个在流感病毒感染后激活的TE家族。与其他病原体相比，它们在多种免疫细胞中始终高度活化。我们还发现，这些病原体特异性的家庭大多是在灵长类动物之前整合在进化过程中。

We have identified transposable elements (TEs) that are induced by salmonella but not by influenza virus infection in human macrophages last year. We further collected available RNA-seq datasets in immune cells following different pathogen infection separately.This year, We further identified 34 TE families that are highly activated following ebolavirus infection and 43 TE families are activated following influenza infection. They were consistently highly activated in multiple immune cells compared to other pathogens. We also found that these pathogen-specific families are mostly integrated before primates during evolution.