Transposable Elements at the Crossroads of Evolution, Health and Disease

处于进化、健康和疾病十字路口的转座元件

• 批准号: 10750852
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-13 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10750852
• 关键词: Academia; Acceleration; Address; Affect; Aging; Area; Automobile Driving; Basic Science; Bioinformatics; Biological; Biology; Biomedical Research; British Columbia; Burn injury; Canada; Collaborations; DNA Transposable Elements; Development; Disease; Educational workshop; Elements; Environmental Science; Epigenetic Process; Evolution; Genome; Genome engineering; Genomics; Health; Human; Human Biology; Industry; International; Knowledge; Learning; Life; Methodology; Mobile Genetic Elements; Molecular; Nature; Nerve Degeneration; Organism; Outcome; Pathologic; Plants; Play; Population; Process; Property; Proteomics; Research; Research Personnel; Role; Scientist; Shapes; Technology; Time; Work; carcinogenesis; clinical practice; improved; insight; interest; next generation; posters; symposium; tool development; transposon/insertion element

ABSTRACT Support is requested for a Keystone Symposia conference entitled Transposable Elements at the Crossroads of Evolution, Health and Disease, organized by Drs. Kathleen Burns, Harmit Malik and Irina Arkhipova. The conference will be held in Whistler, British Columbia, Canada from September 3-6, 2023. Transposable elements are omnipresent in every domain of life and play an eminent role in shaping biological properties of living organisms. The field of transposon research has significantly expanded with the realization that mobile DNA constitutes a major component of most genomes and that transposable element sequences, while generally mutagenic, can be co-opted to benefit the host species. Moreover, rapid development of tools to study transposon activities enables the efforts to differentiate their causal and epiphenomenal effects. There is a pressing need to understand the many ways in which mobile DNA affects genome evolution and shapes its function under normal and pathological states. The aims of this conference are to: 1) Apply recent advances in genomics, proteomics and bioinformatics towards an overview of transposon integration into genomic compartments, epigenetic processes and regulatory networks over evolutionary time scales; 2) Expand structural and mechanistic insights into the nature of transposition processes affecting genome dynamics and integrity; 3) Close the gaps in understanding transposon mobilization and its control at the molecular, cellular, organismal, and population levels, highlighting the impact on carcinogenesis, neurodegeneration and aging; 4) Showcase the applications of fundamental knowledge on mobile element-host interactions to the burgeoning fields of genome engineering, biomedicine, plant and environmental sciences. Accelerating advances in the field will attract new investigators who will benefit greatly from this conference, while giving the long-standing experts reasons to reconvene, share methodologies, and promote new collaborations between leading international groups on the broadest possible scale, exploring all kingdoms of life.

摘要 请求支助题为《十字路口的可转位元素》的Keystone专题讨论会 进化、健康和疾病，由凯瑟琳·伯恩斯博士、哈米特·马利克博士和伊琳娜·阿希波娃组织。这个 会议将于2023年9月3日至6日在加拿大不列颠哥伦比亚省惠斯勒举行。 转座因子在生命的各个领域无处不在，在塑造生物方面起着举足轻重的作用 生物有机体的特性。转座子的研究领域随着转座子的实现而显著扩大 移动DNA构成了大多数基因组的主要组成部分，转座元件序列， 虽然通常具有突变性，但可以被增选以造福于宿主物种。此外，工具的快速发展 研究转座子的活动有助于区分它们的因果效应和表象效应。那里 迫切需要了解移动DNA如何影响基因组进化并塑造其 在正常和病理状态下工作。这次会议的目的是：1)将最新进展应用于 基因组学、蛋白质组学和生物信息学--转座子整合到基因组中的研究进展 进化时间尺度上的隔间、表观遗传过程和调控网络；2)扩展 对影响基因组动力学和基因组动力学的转座过程的本质的结构和机制的见解 完整性；3)弥合在分子，细胞， 生物和种群水平，突出对致癌、神经退化和衰老的影响；4) 展示移动元素-主机交互的基础知识在蓬勃发展的 基因组工程、生物医学、植物和环境科学等领域。加快推进 菲尔德将吸引新的调查人员，他们将从这次会议中受益匪浅，同时给予长期存在的 专家再次召开会议、分享方法并促进领先企业之间的新协作的理由 最大规模的国际组织，探索生命的所有王国。