Self-Powered Photoelectrochemical Device for Ultrasensitive Virus Detection using Multi-component Nanoheterostructure

自供电光电化学(PEC)传感器最近在医疗保健系统中引起了极大的关注。PEC检测继承了电化学和光学技术的优点，因为光驱动电化学反应是PEC分析的基础，因此有必要增加相关的PEC信号以进行灵敏检测。目前，对光诱导载流子的产生、分离和界面氧化还原反应机理的研究对于实现有效的PEC检测是至关重要的。然而，光生载体的缓慢界面相互作用，以及需要合适的光敏层用于传感，继续对复杂的PEC平台的发展构成障碍。本工作的重要成果是利用空心球、棒状物和量子点形成了具有良好结构的Co3O4-CdSe-CDS-Pt光催化剂，可以在一定的距离上调节铂和Co3O4的位置，从而调节空穴和电子的复合速率，提高光催化性能。检测信号主要基于新型电催化剂Co3O4-CdSe-CDS-Pt在可见光激发下产生的光电流响应。为了放大检测信号，Co3O4-CdSe-CDS-PT将被包裹在脂质体中，与抗体一起功能化。将Co3O4-CdSe-CDS-PT脂质体与病毒偶联，然后进行磁分离，可以使分析信号随着病毒浓度的变化而变化。

Self-powered photoelectrochemical (PEC) sensors have recently attracted a lot of attention in healthcare systems. PEC detection inherits the benefits of both electrochemical and optical techniques as the photodriven electrochemical reaction is fundamental to PEC analysis, making it necessary to increase the associated PEC signals for sensitive detection. Investigations into the production, separation, and interfacial-redox-reaction mechanisms of photoinduced carriers are crucial for the realization of effective PEC detection at present. However, the slow interfacial interactions of the photogenerated carriers, as well as the necessity for suitable photoactive layers for sensing, continue to pose obstacles to the development of sophisticated PEC platforms. The important achievement in this work is well-defined novel architecture of Co3O4-CdSe-CdS-Pt using hollow sphere, rod and quantum dot allowing to adjust Pt and Co3O4 position at a particular distance regulates the hole and electron recombination rate, improving the photo-catalytic performance. The detection signal is majorly based on the photo current response generated by novel electrocatalyst Co3O4-CdSe-CdS-Pt upon excitation with visible light. For the amplification of the detection signal, Co3O4-CdSe-CdS-Pt will be encapsulated inside the liposome, functionalized with antibodies. Conjugating the Co3O4-CdSe-CdS-Pt encapsulated liposomes with virus, followed by magnetic separation allows the variation of analytical signal in response to virus concentration.