Self-Powered Photoelectrochemical Device for Ultrasensitive Virus Detection using Multi-component Nanoheterostructure

自供电光电化学（PEC）传感器近年来在医疗保健系统中引起了广泛的关注。PEC检测继承了电化学和光学技术的优点，因为光驱动的电化学反应是PEC分析的基础，因此有必要增加相关的PEC信号以进行敏感检测。研究光诱导载流子的产生、分离和界面氧化反应机理是实现有效的光电耦合检测的关键。然而，光生载流子缓慢的界面相互作用，以及合适的光活性层用于传感的必要性，继续对复杂的PEC平台的发展构成障碍。本工作的重要成果是明确了Co3O4- cdse - cds -Pt的新结构，利用空心球体、棒状结构和量子点，可以在特定距离上调节Pt和Co3O4的位置，调节空穴和电子的复合速率，提高光催化性能。检测信号主要基于新型电催化剂Co3O4-CdSe-CdS-Pt在可见光激发下产生的光电流响应。为了扩增检测信号，Co3O4-CdSe-CdS-Pt将被包裹在脂质体内，并被抗体功能化。将Co3O4-CdSe-CdS-Pt包封脂质体与病毒偶联，然后进行磁分离，使分析信号随病毒浓度的变化而变化。

Self-powered photoelectrochemical (PEC) sensors have recently attracted a lot of attention in healthcare systems. PEC detection inherits the benefits of both electrochemical and optical techniques as the photodriven electrochemical reaction is fundamental to PEC analysis, making it necessary to increase the associated PEC signals for sensitive detection. Investigations into the production, separation, and interfacial-redox-reaction mechanisms of photoinduced carriers are crucial for the realization of effective PEC detection at present. However, the slow interfacial interactions of the photogenerated carriers, as well as the necessity for suitable photoactive layers for sensing, continue to pose obstacles to the development of sophisticated PEC platforms. The important achievement in this work is well-defined novel architecture of Co3O4-CdSe-CdS-Pt using hollow sphere, rod and quantum dot allowing to adjust Pt and Co3O4 position at a particular distance regulates the hole and electron recombination rate, improving the photo-catalytic performance. The detection signal is majorly based on the photo current response generated by novel electrocatalyst Co3O4-CdSe-CdS-Pt upon excitation with visible light. For the amplification of the detection signal, Co3O4-CdSe-CdS-Pt will be encapsulated inside the liposome, functionalized with antibodies. Conjugating the Co3O4-CdSe-CdS-Pt encapsulated liposomes with virus, followed by magnetic separation allows the variation of analytical signal in response to virus concentration.