In vivo mechano-microscopy: a discovery platform for cell mechanics

体内机械显微镜：细胞力学的发现平台

• 批准号: DP160100019
• 负责人: Prof Brendan Kennedy
• 金额: $ 46.69万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100019
• 关键词: vivo; mechano; microscopy; discovery; platform

This project aims to develop a platform for quantitative 3-D imaging of cell elasticity in tissue which may make possible new discoveries in cell mechanics. Mechanical properties, in concert with chemical properties, act to determine the function and behaviour of cells, and play a vital role in diseases such as cancer. Measurement of the mechanical properties of the cell in its native tissue environment, currently not possible, could accelerate the understanding of cell mechanics. This project plans to develop in vivo mechano-microscopy by combining innovations in optical microscopy, micro-mechanical loading, and computational methods. It then plans to demonstrate its capability by producing the first 3-D elasticity maps of skeletal muscle cells in living animals.

该项目旨在开发一个组织中细胞弹性的定量三维成像平台，这可能会使细胞力学的新发现成为可能。机械性质与化学性质一起决定了细胞的功能和行为，并在癌症等疾病中起着至关重要的作用。测量细胞在其天然组织环境中的机械特性，目前是不可能的，可以加速对细胞力学的理解。该项目计划通过结合光学显微镜，微机械加载和计算方法的创新来开发体内机械显微镜。然后，它计划通过制作活体动物骨骼肌细胞的第一个三维弹性图来展示其能力。