Dynamic Mechano-Microscopy for use in Mechanobiology

用于力学生物学的动态力学显微镜

• 批准号: DP220100163
• 负责人: Prof Brendan Kennedy
• 金额: $ 33.93万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-10 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220100163
• 关键词: Dynamic; Mechano; Microscopy; use; Mechanobiology

We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understanding of cells, the building blocks of life. We will achieve this by: 1. Developing a microscope that combines microscopic resolution with rapid imaging; 2: Developing the capability to image both within the cell and its surrounding environment; and 3. Using our microscope to make discoveries in biology.

我们将开发一种创新的显微镜，使生物学的新发现。大多数显微镜形成样品的光学性质的图像，而不是我们将图像的样品的机械性能。需要我们的新方法的原因是细胞行为取决于其环境的硬度，但目前的显微镜无法成像。我们的显微镜将提供生物学方面的见解，可以提高我们对细胞的理解，细胞是生命的基石。我们将通过以下方式实现这一目标：1.开发一种结合了显微分辨率和快速成像的显微镜; 2：开发在细胞及其周围环境中成像的能力;以及3。利用我们的显微镜来发现生物学。