Development of new treatment options in patients with cervical cancer who are unsuitable for intracavitary brachytherapy

为不适合腔内近距离放射治疗的宫颈癌患者开发新的治疗方案

• 批准号: 22K15813
• 负责人: 伊藤 慶
• 金额: $ 1.91万
• 依托单位: Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Komagome Hospital
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K15813/
• 关键词: 子宮頸癌; 体幹部定位放射線治療; 臨床試験

1. 腔内照射不適な子宮頸癌に対するSBRTを行う第I/II相試験の経過観察期間が終了した。結果の概要としては、重篤な有害反応を起こすことなく、標準治療である腔内照射の成績と同等程度の極めて良好な有効性が示された。1-1. 得られた結果を欧州放射線腫瘍学会で発表した。1-2. 得られた結果を日本放射線腫瘍学会で発表予定である。1-3. 論文執筆し、英文誌「Clinical Oncology」に投稿した（査読中）。2. 腔内照射とSBRTの線量分布を比較する前向き研究を実施し、患者登録を終えた。17人の患者の放射線治療計画を比較し、SBRT群で線量カバレッジが良好である傾向が認められた。2-1. 共同研究者より、結果を米国放射線腫瘍学会で発表予定である。2-2. 近日論文化予定である。3. 子宮頸癌を有する高齢者へのSBRTに関する第II相試験を立案した。プロトコールの暫定版は完成し、当院婦人科医と詳細を検討している。

1. The symptoms of intracavitary irradiation discomfort, cervical cancer, SBRT, and phase I/II examination have not ended during the examination period. The summary of the results is as follows, the adverse effects of severe adverse reaction are as follows, and the standard treatment as intracavitary irradiation is as good as the results and the effectiveness is as good as the same degree. 1-1. The results are obtained from the European Radiation Oncology Society's report. 1-2. The results are determined by the Japanese Radiation Oncology Society. 1-3. Wrote the paper and submitted it to the English journal "Clinical Oncology" (checked). 2. Comparison of the dose distribution of intracavitary irradiation and SBRT, forward-looking study, and patient registration. The results of the comparison of radiation treatment plans and SBRT group results for 17 patients showed that the radiation dose was good and the tendency was good. 2-1. The co-investigator is Yu, and the results are specified by the American Radiation Oncology Society. 2-2. Recently, culture has been decided. 3. If you have cervical cancer and are of high age, you will be registered in the SBRT II phase examination. The tentative version of プロトコールの has been completed, and the details of the gynecology department at the hospital have been discussed.

项目成果

A phase I/II study of SBRT boost in patients with cervical cancer who are ineligible for ICBT

对不适合 ICBT 的宫颈癌患者进行 SBRT 强化的 I/II 期研究

• 发表时间: 2023
• 作者: N. C. Luong;H. Kawamura;H. Ikeda;R. T. Roppongi;K. D. Held;Kei Ito
• 通讯作者: Kei Ito