Nutritional approach for the cognitive frailty prevention: a 22-years cohort study of older Japanese community-dwellers.

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This study aims to elucidate: 1) dietary factors that play important roles in preventing cognitive frailty (CF) (through different pathways); 2) possible mechanisms of any associations identified; and 3) risk factors modifying nutrition approaches for preventing and improving CF.My main task this year was to verify the reliability and validity of the Memory Complaint Questionnaire in Japanese (MAC-Q-J) through a web-based survey. Additionally, I studied the impact of dietary diversity on the transition from robustness to CF using 14 years of cognitive function and frailty data. I found that high dietary diversity can reduce the progression from robustness to mild cognitive impairment (MCI)/frailty and from frailty to CF in a multi-state model.