Harnessing knowledge of lifespan biological, health, environmental and psychosocial mechanisms of cognitive frailty for integrated interventions

利用认知脆弱的生命周期生物、健康、环境和心理社会机制知识进行综合干预

• 批准号: BB/W018322/1
• 负责人: Carol Ann Holland
• 金额: $ 36.4万
• 依托单位: Lancaster University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW018322%2F1
• 关键词: Harnessing; knowledge; lifespan; biological; health

The primary aim of the Cognitive Frailty Interdisciplinary Network (CFIN) is to promote collaborative, multidisciplinary research that moves along the pathway from basic laboratory studies through to having a real impact on lives. The focus is on research that addresses the challenge of alleviating the development of age-related cognitive frailty and related reduced healthspan (years, or proportion of one's life spent in good health), and poor quality of life. Cognitive frailty is defined as a variable condition characterised by simultaneous presence of physical frailty and age-related cognitive impairment, but the exclusion of existing dementia. The issue of age-related cognitive frailty is a major societal challenge in terms of its increasing impact on quality of life in our ageing populations, but it is also a challenge in terms of bringing together research from diverse fields. Currently, much research on ageing takes place within disciplines. We are thus beginning to learn much about the biological mechanisms of the ageing process, the psychological and neurophysiological processes of cognitive ageing and the external environmental, social or personal health behaviour factors that impact on the development of frailty or cognitive decline in humans. Despite this wealth of knowledge already available on cognitive ageing, there has been little discourse and knowledge exchange between disciplines such that there has been little progress in recent years in finding multi-dimensional interventions to prevent, rehabilitate, or reduce progress in cognitive frailty in later life. This network aims to bridge the gaps between basic, clinical and social science research to foster the translation of the scientific understanding of ageing. The objectives are focused on building and operationalising an important network in this area across disciplines including Biology, neuroscience, psychology, epidemiology, social science and citizen engagement, with an array of linked network support organisations including the NHSA and the National Innovation Centre for Ageing. With links to the NIHR NWC ARC, the use of a health inequalities assessment tool (the HIAT) will be incorporated into all research and activity outcomes of this network, to ensure that everything we do attempts to address, rather than make inequalities worse. The network is ideally constructed to deliver impact, with a significant international External Advisory Group (EAG) in place, an experienced PI/Co-I team, and an initial group of expert members across leading institutions. In addition to building the network Nationally and Internationally, via our own discipline networks, multidisciplinary research centres, learned societies, and via the network conference to be held early on, outcomes include production of a consensus paper on multi-factor pathways for intervention, an evidence synthesis of the interaction between biological mechanisms and external predictors of cognitive frailty, a series of mini-project development studies, and from these, a series of larger multidisciplinary outcome research proposals. Capacity development, particularly the development of Early Career Researchers (ECRs) will be a focus, with a mentorship programme whereby cross-disciplinary mentoring partnerships are set-up. We will also invite Co-Is and members to submit ideas for an ECR mini-conference/summer school. Involvement of older adults and other stakeholders such as carers is a crucial part of this network, which will be supported by the inclusion of a Co-I from VOICE, a well-established organisation that harnesses the mental capital, insights, and ideas of the public. They will be able to strengthen the reach and diversity of meaningful public engagement and participation in the mini collaborative projects and across the network. VOICE will strengthen links to and collaboration between citizens and a range of voluntary and community organisations (including charities).

认知脆弱跨学科网络（CFIN）的主要目的是促进合作，多学科研究，沿着从基础实验室研究到对生活产生真实的影响的道路前进。重点是研究如何缓解与年龄有关的认知能力下降和相关的健康寿命缩短（年数，或一个人一生中健康状况良好的比例）以及生活质量差的挑战。认知脆弱被定义为一种可变的条件，其特征是同时存在身体虚弱和年龄相关的认知障碍，但排除现有的痴呆症。与年龄有关的认知能力薄弱问题是一个重大的社会挑战，因为它对我们老龄人口的生活质量的影响越来越大，但它也是一个挑战，因为它汇集了来自不同领域的研究。目前，许多关于老龄化的研究都是在学科范围内进行的。因此，我们开始对衰老过程的生物机制、认知老化的心理和神经生理过程以及影响人类脆弱或认知能力下降的外部环境、社会或个人健康行为因素有了更多的了解。尽管已经有了关于认知老化的丰富知识，但学科之间的话语和知识交流很少，因此近年来在寻找多维干预措施以预防，康复或减少晚年认知脆弱的进展方面几乎没有进展。该网络旨在弥合基础、临床和社会科学研究之间的差距，以促进对老龄问题的科学理解的转化。目标的重点是在这一领域建立和运作一个跨学科的重要网络，包括生物学，神经科学，心理学，流行病学，社会科学和公民参与，以及一系列相互联系的网络支持组织，包括NHSA和国家老龄化创新中心。通过与NIHR NWC ARC的链接，健康不平等评估工具（HIAT）的使用将被纳入该网络的所有研究和活动成果，以确保我们所做的一切都试图解决，而不是使不平等变得更糟。该网络的理想结构是提供影响，具有重要的国际外部咨询小组（EAG），经验丰富的PI/Co-I团队以及领先机构的专家成员的初始小组。除了通过我们自己的学科网络、多学科研究中心、学术团体和早期举行的网络会议在国家和国际两级建立网络外，成果还包括编写关于多因素干预途径的共识文件、生物机制与认知脆弱外部预测因素之间相互作用的证据综合、一系列小型项目开发研究、并从中提出一系列更大的多学科成果研究建议。能力发展，特别是早期职业研究人员的发展将是一个重点，通过一个导师方案，建立跨学科的导师伙伴关系。我们还将邀请Co-Is和成员提交ECR小型会议/暑期学校的想法。老年人和其他利益相关者（如护理人员）的参与是该网络的重要组成部分，该网络将得到VOICE的Co-I的支持，VOICE是一个成熟的组织，利用公众的精神资本，见解和想法。他们将能够加强有意义的公众参与的范围和多样性，并参与小型合作项目和整个网络。VOICE将加强公民与一系列志愿和社区组织（包括慈善机构）之间的联系和合作。

项目成果

Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

了解认知脆弱的外源因素和生物机制：多学科范围审查

• DOI: 10.1101/2024.01.18.24301491
• 发表时间: 2024
• 作者: Holland C

Green spaces and the impact on cognitive frailty: a scoping review.

• DOI: 10.3389/fpubh.2023.1278542
• 发表时间: 2023
• 期刊: FRONTIERS IN PUBLIC HEALTH
• 影响因子: 5.2
• 作者: Davis, Sally Fowler;Benkowitz, Charlotte;Nield, Lucie;Dayson, Chris
• 通讯作者: Dayson, Chris

A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty

• DOI: 10.3390/environments11010004
• 发表时间: 2023-12
• 期刊: Environments
• 影响因子: 3.7
• 作者: James Robert Hodgson;Charlotte Benkowitz;Brian C. Castellani;Amanda Ellison;Rammina Yassaie;Helen Twohig;R. Bhudia;O. Jutila;Sally Fowler-Davis