Pathophysiological model to recapitulate the progression of pancreatic ductal adenocarcinoma metastasized to the liver.

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The differentiation of hiPSCs-derived tumor models has been achieved with several cell lines. Depending on the cancer cell line used for the induction, the models were found to express markers typical of cancer stem cells, tumor-associated macrophages, and cancer-associated fibroblasts. The function has also been tested for those cell types in terms of proteins such as Ki67. The different models have been sorted to investigate the percentage in each cell type of each model. The project has been prematurely ended due to a change of employment of the principal investigator.