Pathophysiological model to recapitulate the progression of pancreatic ductal adenocarcinoma metastasized to the liver.

病理生理学模型概括胰腺导管腺癌转移至肝脏的进展。

• 批准号: 22K18182
• 负责人: DANOY MATHIEU
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K18182/
• 关键词: Tumor; Pancreas; Liver; hiPSCs; Stroma; Fibroblasts; Macrophages; Cancer; PDAC; Metastasis; Pathophysiology

The differentiation of hiPSCs-derived tumor models has been achieved with several cell lines. Depending on the cancer cell line used for the induction, the models were found to express markers typical of cancer stem cells, tumor-associated macrophages, and cancer-associated fibroblasts. The function has also been tested for those cell types in terms of proteins such as Ki67. The different models have been sorted to investigate the percentage in each cell type of each model. The project has been prematurely ended due to a change of employment of the principal investigator.

已经用几种细胞系实现了hiPSC衍生的肿瘤模型的分化。根据用于诱导的癌细胞系，发现模型表达癌症干细胞、肿瘤相关巨噬细胞和癌症相关成纤维细胞的典型标志物。该功能也已在这些细胞类型的蛋白质如Ki67方面进行了测试。已对不同模型进行分类，以研究每个模型的每个细胞类型中的百分比。由于主要研究者的就业变化，该项目已提前结束。