Mechanosensitive cGMP signalling in platelets (A05)

血小板中的机械敏感 cGMP 信号传导 (A05)

• 批准号: 406379593
• 金额: --
• 依托单位: Interfakultäres Institut für Biochemie (IFIB)
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406379593?language=en
• 关键词: Mechanosensitive; cGMP; signalling; platelets; A05

The cyclic nucleotide cGMP is an important signalling molecule of our cardiovascular system and increasingly targeted by clinically used drugs. We have discovered a mechanosensitive cGMP pathway (mechano-cGMP) in mouse and human platelets that is organised by a membrane-associated integrin-cGMP signalosome. In this project, we will study the molecular architecture and mode of action of mechano-cGMP as well as its functional and therapeutic relevance in mouse and human. We hypothesise that the novel link between integrin and cGMP signalling provides a flow/shear-sensitive break mechanism to prevent platelet overactivity in platelet-related disorders.

环核苷酸cGMP是我们心血管系统的重要信号分子，并且越来越多地被临床使用的药物靶向。我们在小鼠和人血小板中发现了一种机械敏感性cGMP途径（mechano-cGMP），该途径由膜相关整合素-cGMP信号体组织。在这个项目中，我们将研究mechano-cGMP的分子结构和作用模式，以及其在小鼠和人类中的功能和治疗相关性。我们假设整合素和cGMP信号之间的新联系提供了一种流动/剪切敏感性断裂机制，以防止血小板相关疾病中的血小板过度活性。