FOR 2060: cGMP Signalling in Cell Growth and Survival

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cGMP is an intracellular messenger molecule that is involved in the regulation of diverse physiological functions, for example, in blood vessels, the heart, neurons and sensory cells. The Research Unit investigates how a dysfunction of the cGMP signalling system contributes to the development of degenerative diseases of the cardiovascular and nervous system. The goal is a better understanding of the physiological and pathophysiological roles and therapeutic potential of cGMP. Drugs that modulate the intracellular cGMP level might provide new options to treat degenerative diseases.