Optogenetic approaches to study platelet production and function (A04)

研究血小板生成和功能的光遗传学方法 (A04)

• 批准号: 406379332
• 金额: --
• 依托单位: Lehrstuhl für Experimentelle Biomedizin
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406379332?language=en
• 关键词: Optogenetic; approaches; study; platelet; production

Key regulatory mechanisms of platelet production are only insufficiently understood. In the second funding period, we will continue to study light-regulation of megakaryocytes by our set of optogenetic tools and will develop new light-induced tools to manipulate intracellular localisation of target proteins, which will help us to better study their role in this dynamic and complex process. Further, based on our promising in vitro results from the first funding period, we generated optogenetic transgenic mice, which will allow us to control cellular processes in vivo by light.

血小板生成的关键调控机制还不清楚。在第二个资助期内，我们将继续通过我们的光遗传学工具研究巨核细胞的光调控，并将开发新的光诱导工具来操纵靶蛋白的细胞内定位，这将有助于我们更好地研究它们在这个动态和复杂过程中的作用。此外，基于我们第一个资助期的有希望的体外结果，我们产生了光遗传转基因小鼠，这将使我们能够通过光控制体内细胞过程。