Pharmacological and Optogenetic approaches to study neural control of breathing

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Rhythmic respiratory activity is generated in the brainstem by a network of neurons distributed in the lower medulla and is highly influenced by chemosensitive drive and brain state activity. Our laboratory is interested in how respiratory rhythms are generated and modulated in vivo, especially regarding the functional role of the two proposed brainstem regions that drive inspiratory and expiratory rhythmic activity, respectively, across different stages of development, in different brain state levels and during different neuromodulatory inputs.