Pharmacological and Optogenetic approaches to study neural control of breathing

研究呼吸神经控制的药理学和光遗传学方法

• 批准号: 439547-2013
• 负责人: Pagliardini, Silvia
• 金额: $ 6.84万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506228
• 关键词: Pharmacological; Optogenetic; approaches; study; neural

Rhythmic respiratory activity is generated in the brainstem by a network of neurons distributed in the lower medulla and is highly influenced by chemosensitive drive and brain state activity. Our laboratory is interested in how respiratory rhythms are generated and modulated in vivo, especially regarding the functional role of the two proposed brainstem regions that drive inspiratory and expiratory rhythmic activity, respectively, across different stages of development, in different brain state levels and during different neuromodulatory inputs.

有节律的呼吸活动是由分布在下髓质的神经元网络在脑干中产生的，并且受到化学敏感性驱动和大脑状态活动的高度影响。我们的实验室对体内呼吸节律如何产生和调节感兴趣，特别是关于两个拟议的脑干区域的功能作用，这两个区域分别在不同的发育阶段、不同的大脑状态水平和不同的神经调节输入期间驱动吸气和呼气节律活动。