Structural and functional properties of meprin metalloproteases with regard to cell signaling (A13*)

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The project deals with meprin proteases and their role as shedding enzymes. The amyloid precursor protein, the IL-6 receptor and the β1 integrin are cleaved differentially by meprin α and meprin β. Since meprin α and meprin β exhibit similar cleavage specificities, but do not share all substrates, the existence of exosites must be involved in substrate recognition. The project will identify and target exosites within meprin α and meprin β and analyze functional consequences of meprin β overexpression in vivo with regard to β1 integrin signaling.