Structural and functional properties of meprin metalloproteases with regard to cell signaling (A13*)

meprin 金属蛋白酶在细胞信号传导方面的结构和功能特性 (A13*)

• 批准号: 406426590
• 金额: --
• 依托单位: Institut für Funktionelle und Klinische Anatomie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406426590?language=en
• 关键词: Structural; functional; properties; meprin; metalloproteases

The project deals with meprin proteases and their role as shedding enzymes. The amyloid precursor protein, the IL-6 receptor and the β1 integrin are cleaved differentially by meprin α and meprin β. Since meprin α and meprin β exhibit similar cleavage specificities, but do not share all substrates, the existence of exosites must be involved in substrate recognition. The project will identify and target exosites within meprin α and meprin β and analyze functional consequences of meprin β overexpression in vivo with regard to β1 integrin signaling.

该项目涉及meprin蛋白酶及其作为脱落酶的作用。淀粉样蛋白前体蛋白、IL-6受体和β1整合素被meprin α和meprin β不同程度地切割。由于meprin α和meprin β具有相似的裂解特异性，但不共享所有底物，因此外源位点的存在一定参与了底物识别。该项目将确定和定位meprin α和meprin β中的外源位点，并分析meprin β在体内过表达对β1整合素信号传导的功能影响。