Proteolytic generation of the soluble interleukin-6 receptor in vivo (A14*)

体内可溶性白细胞介素 6 受体的蛋白水解生成 (A14*)

• 批准号: 406426656
• 金额: --
• 依托单位: Biochemisches Institut
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406426656?language=en
• 关键词: Proteolytic; generation; soluble; interleukin; receptor

The project deals with the soluble IL-6R in the circulation. This protein is generated by ADAM17-independent proteolysis since humans and mice without detectable ADAM17 activity exhibit normal soluble IL-6R levels. The level of soluble IL-6R is a critical determinant of susceptibility to inflammatory diseases. The project will identify the proteolytic activity responsible for the generation of the steady-state soluble IL-6R serum levels. We will screen candidate proteases and validate their involvement in sIL-6R generation with corresponding knock-out mouse models.

该项目涉及循环中的可溶性 IL-6R。该蛋白质是通过不依赖 ADAM17 的蛋白水解作用产生的，因为没有检测到 ADAM17 活性的人类和小鼠表现出正常的可溶性 IL-6R 水平。可溶性 IL-6R 水平是炎症性疾病易感性的关键决定因素。该项目将确定产生稳态可溶性 IL-6R 血清水平的蛋白水解活性。我们将筛选候选蛋白酶并用相应的敲除小鼠模型验证它们在 sIL-6R 生成中的参与。