Clinical Paths for Soluble Epoxide Hydrolase Inhibitors at Experimental Biology 2018

项目摘要/摘要： 该提案要求为研究生和博士后学者提供参加2018年 ASPET/实验生物学会议(EB2017)于4月21日至25日在加利福尼亚州圣地亚哥举行至今 在题为“可溶性环氧化物水解酶抑制剂的临床途径”的会议上张贴海报。这件事的重点是 研讨会的目的是促进对环氧化物水解酶在人类健康中的了解，同时提供 展示海报的年轻科学家和演讲的资深科学家之间的思想交流。EB2017是 一个由所有领域的生物学家广泛参加的会议，从而提供了一个理想的环境来推动两者的发展 研究和培训目标使人们更透彻地了解环氧化物水解酶在 人类健康和更快地识别生物靶标的异物毒性效应。 环氧化物水解酶已被证明可以代谢外源化合物和内源环氧化物中的环氧化物， 例如来自花生四烯酸的环氧二十碳三烯酸(EETs)。因此，它们是两种酶的关键酶。 化学物质在体内的降解和调节毒性以及在调节环氧基脂肪酸维持中的作用 各种系统中的动态平衡。放松对EETs的管制与几种疾病有关 如心血管疾病、糖尿病、炎症和神经病理性疼痛。最近，有一种 在各种疾病中抑制sEH的潜在临床路径的显著扩展，但也强调 环境污染物如何通过调节高杠杆生物来影响人类健康 靶标‘，如环氧化物水解酶。 会议和海报会议的广泛和长期目标是推动环氧化物领域的发展 通过鼓励高级研究人员在研讨会上发表演讲和 实习生展示海报。这次会议的具体目的是鼓励年轻的研究人员参加 一次大型会议，并与其研究领域的领导者互动，以提供该领域的更广泛视角 以更快的速度产生协作和知识。 环氧化物水解酶的研究领域正在取得显著进展，因为有更多的证据表明环氧化物水解酶 在生物系统中的作用。EB2018会议将为该领域的主要领导者提供一个机会 讨论环氧化物水解酶研究的最新进展，并与初级科学家分享研究结果。

Project Summary/Abstract: This proposal requests travel funds for graduate students and postdoctoral scholars to attend the 2018 ASPET/Experimental Biology Conference (EB2017) from April 21-25 in San Diego, California to present posters in the session titled, “Clinical Paths for Soluble Epoxide Hydrolase Inhibitors”. The focus of this symposium is to advance the understanding of epoxide hydrolases in human health while providing the exchange of ideas between younger scientists presenting posters and senior scientists giving talks. EB2017 is a widely attended conference by biologists of all fields, thus offering an ideal environment to advance both research and training goals resulting in a more thorough understanding of the role epoxide hydrolases play in human health and a faster identification of biological targets of xenobiotic toxic effects. Epoxide hydrolases have been shown to metabolize epoxides from xenobiotics and endogenous epoxides, such as epoxy-eicosatrienoic acids (EETs) from arachidonic acid. Thus, they are key enzymes for both degrading and regulating chemicals in vivo toxicity and in modulating epoxy-fatty acids to maintain homeostasis in various systems. The deregulation of the EETs has been associated with several illnesses such as cardiovascular diseases, diabetes, inflammation and neuropathic pain. Recently, there has been significant expansion of the potential clinical paths for sEH inhibition in various diseases, but also emphasizes how environmental contaminants can influence human health through modulating a ‘high leverage biological target’ such as epoxide hydrolases. The broad and long-term goals of the conference and poster session is to advance the field of epoxide hydrolase research by encouraging interactions between senior investigators giving talks in a symposium and trainees presenting posters. The specific aims of this meeting will be to encourage young researchers to attend a large conference and interact with leaders in their research field to provide a wider view of the field to generate collaborations and knowledge at a faster pace. The field of epoxide hydrolase research is advancing significantly as more evidence becomes available of their role in biological systems. The session at EB2018 will provide an opportunity for key leaders in the field to discuss the latest advances in epoxide hydrolase research and share findings with junior scientist.