Clinical Paths for Soluble Epoxide Hydrolase Inhibitors at Experimental Biology 2018

2018 年实验生物学中可溶性环氧化物水解酶抑制剂的临床路径

• 批准号: 9544621
• 负责人: BRUCE D HAMMOCK
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9544621
• 关键词: 1,3-Butadiene; Affect; Arachidonic Acids; Area; Biological; Biology; California; Cardiovascular Diseases; Chemicals; Clinical Paths; Collaborations; Development; Diabetes Mellitus; Discipline; Disease; Eicosatrienoic Acid; Environment; Environmental Health; Environmental Pollution; Environmental Risk Factor; Enzymes; Epoxide hydrolase; Epoxy Compounds; Equilibrium; Family; Fatty Acids; Fees; Funding; Glycols; Goals; Grant; Health; Health Occupations; Health Professional; Homeostasis; Human; Inflammation; Knowledge; Mediator of activation protein; Mission; Naphthalene; National Institute of Environmental Health Sciences; Oral; Paper; Pharmaceutical Preparations; Pharmacology and Toxicology; Play; Regulation; Reporter; Request for Proposals; Research; Research Personnel; Research Support; Research Training; Role; Scientist; Senior Scientist; Stress; System; Time; Toxic effect; Training; Training and Education; Travel; United States National Institutes of Health; Work; Xenobiotic Metabolism; Xenobiotics; biological systems; cancer pain; career; clinical application; clinical development; design; environmental stressor; fundamental research; graduate student; in vivo; inhibitor/antagonist; innovation; medical specialties; meetings; next generation; novel; painful neuropathy; posters; programs; recruit; symposium

Project Summary/Abstract: This proposal requests travel funds for graduate students and postdoctoral scholars to attend the 2018 ASPET/Experimental Biology Conference (EB2017) from April 21-25 in San Diego, California to present posters in the session titled, “Clinical Paths for Soluble Epoxide Hydrolase Inhibitors”. The focus of this symposium is to advance the understanding of epoxide hydrolases in human health while providing the exchange of ideas between younger scientists presenting posters and senior scientists giving talks. EB2017 is a widely attended conference by biologists of all fields, thus offering an ideal environment to advance both research and training goals resulting in a more thorough understanding of the role epoxide hydrolases play in human health and a faster identification of biological targets of xenobiotic toxic effects. Epoxide hydrolases have been shown to metabolize epoxides from xenobiotics and endogenous epoxides, such as epoxy-eicosatrienoic acids (EETs) from arachidonic acid. Thus, they are key enzymes for both degrading and regulating chemicals in vivo toxicity and in modulating epoxy-fatty acids to maintain homeostasis in various systems. The deregulation of the EETs has been associated with several illnesses such as cardiovascular diseases, diabetes, inflammation and neuropathic pain. Recently, there has been significant expansion of the potential clinical paths for sEH inhibition in various diseases, but also emphasizes how environmental contaminants can influence human health through modulating a ‘high leverage biological target’ such as epoxide hydrolases. The broad and long-term goals of the conference and poster session is to advance the field of epoxide hydrolase research by encouraging interactions between senior investigators giving talks in a symposium and trainees presenting posters. The specific aims of this meeting will be to encourage young researchers to attend a large conference and interact with leaders in their research field to provide a wider view of the field to generate collaborations and knowledge at a faster pace. The field of epoxide hydrolase research is advancing significantly as more evidence becomes available of their role in biological systems. The session at EB2018 will provide an opportunity for key leaders in the field to discuss the latest advances in epoxide hydrolase research and share findings with junior scientist.

项目概要/摘要： 该提案要求研究生和博士后学者参加2018年的旅行资金 ASPET/实验生物学会议（EB 2017）从4月21日至25日在圣地亚哥，加州至今 在题为“可溶性环氧化物水解酶抑制剂的临床路径”的会议中张贴海报。的重点 研讨会的目的是促进对人类健康中环氧化物水解酶的了解，同时提供 年轻科学家展示海报，资深科学家发表演讲，交流思想。EB 2017是 一个由所有领域的生物学家广泛参加的会议，从而提供了一个理想的环境，以促进双方 研究和培训目标，从而更深入地了解环氧化物水解酶在 人类健康和更快地确定生物外源性毒性效应的生物靶点。 环氧化物水解酶已显示代谢来自外源性物质和内源性环氧化物的环氧化物， 例如来自花生四烯酸的环氧-二十碳三烯酸（EET）。因此，它们是这两种酶的关键酶。 降解和调节化学品的体内毒性，以及调节环氧脂肪酸， 各种系统中的稳态。对Ehrs的放松管制与几种疾病有关 如心血管疾病、糖尿病、炎症和神经性疼痛。最近有 显著扩展了各种疾病中sEH抑制的潜在临床途径，但也强调了 环境污染物如何通过调节“高杠杆生物”来影响人类健康 如环氧化物水解酶。 会议和海报会议的广泛和长期目标是推进环氧化物领域 通过鼓励高级研究人员在研讨会上发表演讲， 学员展示海报。这次会议的具体目标是鼓励年轻研究人员参加 一个大型会议，并与领导人在他们的研究领域，以提供更广泛的视野， 以更快的速度产生协作和知识。 环氧化物水解酶的研究领域正在取得重大进展，因为越来越多的证据表明， 在生物系统中的作用。EB 2018会议将为该领域的主要领导者提供一个机会， 讨论环氧化物水解酶研究的最新进展，并与年轻科学家分享研究成果。