Bismuth Organic Liquid Detector with Cherenkov Light and Charge Readout for Positron Emission Tomography

用于正电子发射断层扫描的具有切伦科夫光和电荷读数的有机铋液体探测器

• 批准号: 406703021
• 负责人: Professor Dr. Klaus Schäfers
• 金额: --
• 依托单位: European Institute for Molecular Imaging (EIMI)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406703021?language=en
• 关键词: Bismuth; Organic; Liquid; Detector; Cherenkov

The aim of the BOLD-PET project is to develop a fast-response, high-efficiency gamma detector with fine grained spatial resolution for positron emission tomography (PET) based on recent developments using the liquid TriMethyl Bismuth (TMBi).This liquid with a bismuth mass fraction of more than 80% allows for a very efficient and accurate detection of 511 keV photons originated from positron annihilation. Bismuth has the highest nuclear charge (Z = 83) and thus the largest photoelectric cross section of all stable isotopes. The gamma energy of 511 keV is transferred to electrons in this material in nearly 50 % of the cases through the photoelectric effect. Both the Cherenkov light emitted by the resulting relativistic photo-electron and the secondary charge carriers produced during multiple scattering interactions are detected in a liquid ionisation chamber, supplemented by photodetectors. Based on previous studies of liquid TMBi, we intend to develop and evaluate a novel PET detector with simultaneous detection of Cherenkov light and ionisation in a common effort of four research partners. Excellent imaging resolution is anticipated with the proposed detector by cancelling out Depth Of Interaction effects while allowing for placement of the detector close to the body which is increasing the detector’s solid angle. The TMBi’s coincidence photoelectric efficiency is the highest available, with twice the value of LSO/LYSO crystals. The new detector should be able to use accurate time-of-flight (TOF) information through Cherenkov light detection in order to improve the contrast of the reconstructed image. To achieve a breakthrough in this challenging project, the expertise of the existing French CaLIPSO group (CEA-IRFU, CNRS-LAL) will be supplemented by the expertise on high-resolution PET imaging and detector development (WWU-EIMI group), and ultra-purification as well as light and charge detector readout (WWU-PHYSICS group), both from University of Münster. The main objective of this collaborative project is to develop a novel detector system for PET imaging (e.g. human brain PET, small animal PET) with a projected efficiency of 30%, high spatial precision of 1mm^3, and high time of flight resolution of 100 ps (FWHM). In order to achieve these objectives the project will focus on the following work areas: (1) ultra-purification of TMBi and further characterisation of TMBi for gamma radiation detection, (2) development of an ionisation detector prototype, (3) study of the Cherenkov photon detection in liquid TMBi, (4) Monte Carlo simulation and image reconstruction of a full PET scanner employing the new technology, and (5) evaluation of a final PET detection demonstrator, merging charge and optical readout.

BOLD-PET项目的目标是开发一种快速响应、高效率的伽马探测器，具有细粒度的空间分辨率，用于正电子发射断层扫描（PET），该探测器基于最近的发展，使用液体三甲基铋（TMBi）。这种液体的铋质量分数超过80%，可以非常有效和准确地探测源自正电子湮灭的511 keV光子。铋具有最高的核电荷（Z = 83），因此是所有稳定同位素中最大的光电截面。 511 keV的伽马能量在近50%的情况下通过光电效应转移到该材料中的电子。 由所产生的相对论性光电子和在多次散射相互作用期间产生的二次电荷载流子发射的切伦科夫光都在液体电离室中被检测到，并由光电探测器补充。 基于以前的液体TMBi的研究，我们打算开发和评估一种新型的PET探测器，同时检测切伦科夫光和电离，这是四个研究伙伴的共同努力。通过消除相互作用深度效应，同时允许将探测器放置在靠近身体的位置，从而增加探测器的立体角，预期所提出的探测器具有出色的成像分辨率。TMBi的符合光电效率是最高的，是LSO/LYSO晶体的两倍。新的探测器应该能够通过切伦科夫光探测使用精确的飞行时间（TOF）信息，以提高重建图像的对比度。为了在这个具有挑战性的项目中取得突破，现有的法国CaLIPSO小组（CEA-IRFU，CNRS-LAL）的专业知识将得到明斯特大学高分辨率PET成像和探测器开发（WWU-EIMI小组）以及超纯化以及光和电荷探测器读出（WWU-PHYSICS小组）的专业知识的补充。 该合作项目的主要目标是开发一种用于PET成像（例如人脑PET、小动物PET）的新型探测器系统，其投影效率为30%，空间精度为1 mm^3，飞行时间分辨率为100 ps（FWHM）。为了实现这些目标，该项目将侧重于以下工作领域：（1）TMBi的超纯化和用于γ辐射检测的TMBi的进一步表征，（2）电离检测器原型的开发，（3）液体TMBi中切伦科夫光子检测的研究，（4）采用新技术的全PET扫描仪的蒙特卡罗模拟和图像重建，以及（5）评估最终PET探测演示器，合并电荷和光学读出。