Development of a new compact centrifugal blood pump system for extracorporeal circulation and its application

新型紧凑型体外循环离心血泵系统的研制及应用

• 批准号: 61870054
• 负责人: KAMIYA Akira
• 金额: $ 2.82万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61870054/
• 关键词: Centrifugal Blood Pump.; Cardiac Assisted Circulation; Left Ventricular Bypass; Myocardial Adaptive Change; RNA Polymerase Activity; RNAポリメラーゼ活性

A new compact centrifugal blood pump system for use for cardiac-assisted circuration has been developed by the project members in the first poject year: The impeller of the pump was connected directly to a miniature DC serevomotor by using a simple-gear coupling. Either pulsatile or nonpulsatile flow was produced by controlling the cuttent supply to the motor. Through in vitro tests, the pump characteristics and the degree of hemolysis were evaluated with regard of the configuration of the casing and the impeller. In accordance with the project grograms. the following results have been obtained.1. The semi-open type impeller having the blade angles at the inlet of 20゜and at the outlet of 50゜was the most appropriate a blood pump.2. The pumpgin capacity and the degree of hemolysis produced by the pump with volute casing were significatly improved at high flow rate region compared with those by the pump without volute casing.In the second project year, to analyse myocardial adaptive change of the nucleic acid metabolism in response to the prolonged left ventrecular (LV) pressure load reduction, LV to aorta bypass experiments were carried out in mongrel dogs using the newly developed system. After 10 hours bypadd with 50 - 80 % reduction compared with the control level of the peak-LV pressure, RNA polymerase activity was measured in purified nuclear preparation from left and right ventricular muscles. The of RNA polymerase activity of left to right ventricular muscule showed to decrease as compared with those of the control group. From thies result, it is suggested that the myocardial nucleic acid metabolism change following pressure load reduction would be originated without so much long period of time, and that the myocardial adaptive change would progress an opposite way against the cardiac hypertrophy process.The whole programs of this project were completed in this year with satisfactory results as described above.

本课题组在第一年研制了一种用于心脏辅助循环的新型紧凑型离心血泵系统：泵的叶轮通过简单的齿轮联轴器直接连接到微型直流伺服电机上。通过控制马达的电流供应产生脉动流或非脉动流。通过体外试验，从泵壳和叶轮的结构方面评价了泵的特性和溶血程度。按照项目程序进行。获得了以下结果。进口叶片角为20 °、出口叶片角为50 °的半开式叶轮最适合作为血泵.在高流量区，带蜗壳泵的泵送能力和溶血程度较不带蜗壳泵有明显改善，在第二个项目年，分析心肌细胞核酸代谢对长时间左室压力负荷降低的适应性变化，利用新研制的系统在杂种犬中进行了左心室至主动脉旁路实验。与对照水平相比，左室峰值压力降低50 - 80%，旁路移植10小时后，在来自左室和右室肌的纯化核制备物中测量RNA聚合酶活性。与对照组相比，左至右心室肌RNA聚合酶活性均下降。结果表明，在不需要很长时间的情况下，心肌细胞的核酸代谢将随着压力负荷的降低而发生变化，心肌细胞的适应性变化将与心肌肥大的过程相反。

项目成果

山本 修三: 医科器械学. 56. 10-11 (1986)

山本修三：医疗仪器。56. 10-11 (1986)

TANAKA, Shinobu: "Effect of afterload reduction on muocardial RNA synthesis under left ventricular bypass" Jpn. J. Artif. Organs. 15(2). 571-574 (1986)

TANAKA, Shinobu：“左心室旁路下后负荷减少对心肌 RNA 合成的影响”Jpn。

Shinobu Tanaka: ASME Journal of Biomechanical Engineering. 109(3). 272-278 (1987)

Shinobu Tanaka：ASME 生物机械工程杂志。

山本修三: 医科器械学. 56(臨時号). 10-11 (1986)

Shuzo Yamamoto：医疗仪器 56（特刊）。

田中志信: 医用電子と生体工学. 24(秋季特別号). 42-43 (1986)

Shishin Tanaka：医疗电子学和生物工程 24（秋季特刊）（1986 年）。