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Control of nosocomial infection -microbial contamination of in-use drugs and its preventive measures-

医院感染控制-使用药品微生物污染及其预防措施-

基本信息

批准号：
16590112
负责人：
KAMIYA Akira
金额：
$ 0.96万
依托单位：
Yamaguchi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590112/
关键词：
parenteral nebulization microbial contamination particulate contamination glass 高カロリー輸液

项目摘要

1.We evaluated particulate and microbial contamination in a total of 192 samples of in-use admixed and unadmixed parenteral nutrition solutions remaining in infusion bags in 10 hospitals. The mean numbers (range) of drug glass ampoules, plastic ampoules, and vials used in a total of 192 admixed solutions were 3.38 (1-13), 0.79 (0-7), and 1.2 (0-8), respectively. The mean number of particles (range) contained in the 192 samples according to the particle size (diameter) was 960.9 (30-9539)/ml for particles ≧1.3μm, 42.8 (0-587)/ml for those ≧5μm, 6.4 (0-146)/ml for those ≧10μm, and 0.09 (0-1)/ml for those ≧50μm. On the other hand, none of the 199 samples showed bacteria or fungi/5ml residual solution. Measures against particulate contamination of admixed parenteral nutrition solutions are neccessary.2.We evaluated the microbial contamination of nebulization solutions in medication cups from a total of 76 ultrasonic nebulizers in use in 10 hospitals. In addition, an interview survey was given to nurses to evaluate the disinfection methods of these ultrasonic nebulizers. Of a total of 76 nebulization solution samples, 11 (14.5%) were contaminated with 10-10^2 colony-forming units (CFU)/ml and 9 (11.8%) with 10^3 - 10^5 CFU/ml. The major contaminants were glucose fermentative bacilli such as Burkholderia cepacia, CDC gr.IV C-2, and Sphingomonas paucimobilis. These results show that disinfection of ultrasonic nebulizers at 24-h intervals is desirable. In particular, when nebulization solutions not containing preservatives are used, disinfection at 24-h intervals is indispensable.

1.我们评估了10家医院共192份输液袋中残留的混合和未混合肠外营养液的颗粒和微生物污染。192种混合溶液中使用的药物玻璃安瓿、塑料安瓿和小瓶的平均数量（范围）分别为3.38（1-13）、0.79（0-7）和1.2（0-8）。按粒径（直径）计算，192个样品的平均颗粒数（范围）为：≧1.3μm为960.9（30-9539）个/ml，≧5μm为42.8（0-587）个/ml，≧10μm为6.4（0-146）个/ml，≧50μm为0.09（0-1）个/ml。另一方面，199个样品中没有细菌或真菌/5ml残留溶液。有必要采取措施防止混合肠外营养液的微粒污染。我们评估了10家医院使用的76台超声雾化器中药杯内雾化液的微生物污染情况。此外，对护士进行访谈调查，评价超声雾化器的消毒方法。76份雾化溶液样品中，11份（14.5%）被10-10^2菌落形成单位(CFU)/ml污染，9份（11.8%）被10^3 -10^ 5 CFU/ml污染。主要污染物为葡萄糖发酵杆菌，如洋葱伯克霍尔德菌、CDC gr.IV C-2和少动鞘氨单胞菌。这些结果表明，超声波雾化器每隔24小时消毒一次是可取的。特别是，当使用不含防腐剂的喷雾溶液时，每隔24小时进行消毒是必不可少的。