Development of intracavitary irradiation system for carcinoma of the bladder

膀胱癌腔内照射系统的研制

• 批准号: 61870063
• 负责人: TSUCHIDA Seigi
• 金额: $ 4.22万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61870063/
• 关键词: Intracavitary Irradiation; Bladder Cancer; Remote After-loading System; Cobalt-60; マイクロ波; 経膀胱鏡的照射法; 軟性膀胱鏡; 腔内照心; ラルストロン; 膀胱癌; 放射線

A variety of therapies have been used to treat bladder cancer, including instillation of radioisotopes, insertion of a central encapsulated radiation source through an indwelling inflatable balloon catheter, interstitial implantation by an open operation and intraoperative electron beam radiation. However, there also are some significant problens when intracavitary irradiation is used.In the past this method unavoidably exposed physicians, nurses and others to radiation, and required an operation, a long irradiation time and hospitalization of the patient. In an attempt to avoid such problems a remote controlled after-coading irradiation system was used to treat patients with bladder tumors. With this technique sufficient large doses of radiation can be delivered to the bladder tumor. We developed two kinfs of specially designed cystoscope for transcystoscopic intracavitary irradiation. One is rigid ctstoscope for spot irradiation of bladder tumor and the other is flexyble cystoscope of which viewing angle can be remotely controled for regional irradiation of bladder tumor with carcinom in situ. Furthermore, whole bladder mucosal irradiation technique for prophylaxis of the recurrence of bladder tumor was reported.

多种疗法已用于治疗膀胱癌，包括放射性同位素滴注、通过留置充气球囊导管插入中央封装放射源、通过开放手术进行间质植入和术中电子束辐射。然而，使用腔内照射也存在一些显着的问题。在过去，这种方法不可避免地使医生、护士和其他人暴露在辐射下，并且需要手术、较长的照射时间和患者住院治疗。为了避免此类问题，使用远程控制后涂层照射系统来治疗膀胱肿瘤患者。通过这种技术，可以将足够大剂量的辐射传递到膀胱肿瘤。我们开发了两种专门设计的膀胱镜用于经膀胱镜腔内照射。一种是用于膀胱肿瘤点照射的硬性膀胱镜，另一种是可远程控制视角的软性膀胱镜，用于对膀胱肿瘤进行原位癌的区域照射。此外，还报道了用于预防膀胱肿瘤复发的全膀胱粘膜照射技术。

项目成果

原田忠: マイクロウェーブサージェリー. 6. 209-213 (1988)

原田正：微波手术。6. 209-213 (1988)

Seigi, Tsuchida: "Intracavitary Irradiation combined with Microwave Coagulation for Carcinoma of the Bladder" 3319. 21-30 (1987)

Seigi, Tsuchida：“腔内照射联合微波凝固治疗膀胱癌”3319. 21-30 (1987)

原田忠: 日本泌尿器科学会雑誌.

原田正：日本泌尿外科协会杂志。

Tadashi Harada: Urologia Internationalis. 43. 179-184 (1988)

原田正：《国际泌尿学》。

Tadashi, Harada: "New Technique of Transcystoacopic Intracavitary Irradiation for Carcinoma of the Urinary Bladder" Japanese Jounal of Urology. 78. 1900-1906 (1987)

Tadashi, Harada：“经膀胱镜腔内照射治疗膀胱癌的新技术”，日本泌尿外科杂志。