Justus-Liebig University Giessen Clinician Scientist Program in Biomedical Research

尤斯图斯-李比希大学吉森生物医学研究临床科学家项目（JLU- career）旨在继续吸引年轻，有才华，积极进取的年轻居民到JLU医学院，并通过提供优秀的生物医学研究项目和临床教育的安全时间来培养他们作为临床科学家的职业生涯。JLU-CAREER过去和未来的成功是由以下因素决定的：临床和生物医学学科的申请人和项目的选拔，跨学科的监督小组，3年1.5年的研究项目时间，快速的临床教育，国际吉森生命科学研究生中心（GGL）“临床科学”部分的结构化教育计划。取得临床科学家证书和额外的学术资格（生物学博士）。轨。博士学位)，并参加指导计划。女性临床科学家的参与得到了指导、战略网络以及确保家庭和事业协调的侧面措施的支持。尽管2019冠状病毒病大流行和对我校IT结构的有害网络攻击，JLU-CAREER在过去三年中已经全面实施并招募了13名临床科学家（第14名CS仍未决定）。在科学上，JLU-CAREER基于三个研究领域（RAs）：“不平衡炎症与感染”，“纤维化修复与重塑”和“癌症进化与进展”。在这里，我们将研究(i)以病原体清除为目的的夸大炎症与通过限制炎症损伤和促进组织再生和修复的策略来保存和重建器官功能之间的微妙平衡。在这种情况下，我们还将致力于识别和研究局部干细胞生态位激活的相关信号通路。我们将（ii）阐明实质器官纤维化和血管/心脏重塑的触发因素，定义驱动上皮再生的相关干细胞和发育途径，我们将解剖纤维化/重塑背后的间充质细胞的表观遗传变化。我们还将（iii）关注肿瘤微环境信号，表观遗传和代谢编程之间的相互作用，作为控制肿瘤恶性和治疗耐药性的关键癌症标志，并开发进一步的早期检测方法和生物标志物，以改善癌症的诊断和治疗。此外，我们将继续（iv）促进RAs之间的交叉受精，使我们能够例如研究良性炎症驱动/相关疾病（如实质器官纤维化或肺血管重构）与恶性转化之间的机制共性。我们所有的活动都旨在将治疗概念转移到临床，因此进行研究者发起的临床/首次人体试验。

The Justus-Liebig University Giessen Clinician Scientist Program in Biomedical Research (JLU-CAREER) aims to continue to attract young, talented, highly motivated young residents to the Faculty of Medicine of the JLU and to foster their career as Clinican Scientists by providing secured time on an excellent biomedical research project alongside with clinical education. The previous and future success of JLU-CAREER is reached by purely excellency-driven selection of applicants and projects from both, clinical as well as biomedical disciplines, an interdisciplinary group of supervisors, secured time on the research project for 1.5 out of 3 years, fast-track clinical education, a structured educational program in the section “Clinical Sciences” of the International Giessen Graduate Center for the Life Sciences (GGL), achievement of a Clinician Scientist certificate and of additional academic qualifications (Dr. biol. hom.; PhD) and participation in a mentoring program. Participation of female clinician-scientists is supported by coaching, strategic networking as well as flanking measures to ensure compatibility of family and career.Despite the COVID pandemic and the deleterious cyber attack to our university´s IT structures, JLU-CAREER has been fully implemented and recruited 13 Clinician Scientists in the past three years (decision on a 14th CS still pending).Scientifically, JLU-CAREER is based on three research areas (RAs) „Imbalanced Inflammation & Infection“, „Fibrotic Repair & Remodelling“ and „Cancer Evolution & Progression“. In here, we will study (i) the delicate balance between exaggerated inflammation aiming at pathogen removal, and preservation and re-establishment of organ function by strategies limiting inflammatory injury and fostering tissue regeneration and repair. In this context, we will also aim to identify and study relevant signaling pathways underlying the activation of the local stem cell niche. We will (ii) elucidate triggering factors in parenchymal organ fibrosis and vascular / cardiac remodeling, define involved stem cells and developmental pathways driving epithelial regeneration, and we will dissect epigenetic changes in mesenchymal cells underlying fibrosis / remodeling. We will also (iii) focus on the interplay between tumor microenvironment signaling, epigenetic and metabolic programming as key cancer hallmarks in controlling tumor malignancy and therapy resistance, and develop further early detection methods and biomarkers for improved cancer diagnosis and therapy. Moreover, we will continue to (iv) promote cross-fertilization between RAs, enabling us to e.g. study mechanistic commonalities between benign inflammation-driven/-associated diseases such as parenchymal organ fibrosis or pulmonary vascular remodeling and malignant transformation. All our activities will aim at a putative transfer of therapeutic concepts into the clinic, hence conductance of Investigator-initiated clinical / first in man trials.