Endocrine communication of renal tubules (C03)

肾小管的内分泌通讯（C03）

• 批准号: 415876826
• 金额: --
• 依托单位: Institut für Physiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/415876826?language=en
• 关键词: Endocrine; communication; renal; tubules; C03

The kidneys are important endocrine organs. In addition to specialized endocrine cells, tubular cells also release autacoids and hormones, which act on adjacent cells of the tubules and the interstitium and thus influence kidney function. Our project aims at a better understanding of the regulation of tubular hormones and of their functional importance in the healthy and diseased kidney. Based on preliminary data, we will focus on the local, tubular renin-angiotensin system and tubular natriuretic peptides. Moreover, new tubular hormones, autacoids and metabolites will be identified and their functional significance will be clarified.

肾脏是重要的内分泌器官。除了专门的内分泌细胞外，肾小管细胞还会释放类胡桃体和激素，作用于邻近的肾小管和间质细胞，从而影响肾功能。我们的项目旨在更好地了解肾小管激素的调节及其在健康和疾病肾脏中的功能重要性。在初步数据的基础上，我们将重点介绍局部、小管性肾素-血管紧张素系统和小管性利钠肽。此外，还将鉴定新的肾小管激素、类胡萝卜素和代谢物，并阐明其功能意义。