Endocrine communication of renal tubules (C03)

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The kidneys are important endocrine organs. In addition to specialized endocrine cells, tubular cells also release autacoids and hormones, which act on adjacent cells of the tubules and the interstitium and thus influence kidney function. Our project aims at a better understanding of the regulation of tubular hormones and of their functional importance in the healthy and diseased kidney. Based on preliminary data, we will focus on the local, tubular renin-angiotensin system and tubular natriuretic peptides. Moreover, new tubular hormones, autacoids and metabolites will be identified and their functional significance will be clarified.