Northwestern University O'Brien Kidney National Resource Center

摘要-NU-NRC总体 肾脏疾病影响着3700万美国人，使他们面临心血管事件的主要风险，其他共同的 病态，和死亡。虽然我们的领域最近取得了令人兴奋的进展，但要影响这些令人震惊的 数字，关键是找出新的治疗靶点，扩大我们对疾病发病机制和 开发新的方法来靶向肾脏中的特定细胞类型。要做到这一点，我们必须突破学科界限， 搭建新的发现平台，与正交学科合作。肾脏领域尚未解决的重大挑战 研究缺乏能够结合肾脏复杂性和多样性的技术和平台 结构、细胞表型和功能在其设计和执行中的作用。拟建的西北大学 大学国家资源中心(NU-NRC)将通过利用 物理科学为肾脏研究人员提供独特的工具、试剂和平台。经过设计，这些 资源利用了组织和细胞的多样性，使它们成为发现的强大技术- 基于肾脏的研究和治疗开发。 NU-NRC的总体主题是采用强大的物理科学理论、工具、平台和 在物理科学中推进肾脏研究的方法-肾脏资源中心。少校 该中心的目标是：A)利用物理科学的进步，提供新的方法来解决未满足的问题 肾脏研究和发现方面的挑战，以及B)提供方便地获取物理科学工具、试剂 以及更广泛的肾脏社区的平台，以催化他们的研究和刺激创新。我们会 通过四个具体目标实现这些目标：1.建立以以下为重点的生物医学资源核心 已建立的纳米技术方法用于特定于细胞的治疗和诊断有效载荷(小的 分子和生物制品)2.建立以新兴技术为重点的资源开发核心 不同领域的物理科学，以促进肾脏研究。3.建立一个行政核心来监督 中心的所有操作，并确保新技术随时可用于肾脏研究 社区和4.为高中生提供身临其境的暑期科学高中研究项目。 一支敬业、精力充沛、才华横溢的西北大学和 南加州大学将确保NU-NRC履行其使命，通过 物理科学解决方案，并推动我们更接近实现其大胆的愿景：物理科学解决方案治愈 肾脏疾病。

SUMMARY – NU-NRC OVERALL Kidney diseases affect 37 million Americans, placing them at major risk for cardiovascular events, other co- morbidities, and death. While there have been exciting recent advances in our field, to impact these staggering numbers, it is critical to identify new therapeutic targets, expand our understanding of disease pathogenesis and develop new methods to target specific cell types in the kidney. To do this, we must push disciplinary boundaries, build new discovery platforms and partner with orthogonal disciplines. A major unmet challenge in kidney research is the dearth of technologies and platforms that can incorporate the complexity and diversity of kidney structure, cellular phenotypes and function in their design and execution. The proposed Northwestern University National Resource Center (NU-NRC) will meet this challenge by leveraging innovations in the physical sciences to provide unique tools, reagents, and platforms to kidney researchers. By design, these resources take advantage of tissue and cellular diversity, making them powerful technologies for discovery- based kidney research and therapeutic development. The overarching theme of the NU-NRC is to adapt powerful physical sciences theory, tools, platforms, and approaches to advance kidney investigation in a Physical Sciences-Kidney Resource Center. The major goals of the Center are to A) harness physical science advances to provide new approaches to solve unmet challenges in kidney research and discovery, and B) to provide easy access to physical science tools, reagents and platforms to the broader kidney community to catalyze their research and spur innovation. We will accomplish these goals through four specific aims: 1. Establish a Biomedical Resource Core focused on established nanotechnology methods for cell-specific delivery of therapeutic and diagnostic payloads (small molecules and biologics) 2. Establish a Resource Development Core focused on nascent technologies in diverse areas of physical sciences to catalyse kidney research. 3. Establish an Administrative Core to oversee all operations of the Center and ensure new technologies are made readily available to the kidney research community and 4. Provide an immersive summer SciHigh research program for high school students. A dedicated, energetic and talented transdisciplinary scientific and administrative team at Northwestern and the University of Southern California will ensure NU-NRC fulfills its mission to transform kidney research through physical science solutions and move us closer to realizing its bold vision: physical science solutions to cure kidney diseases.