Northwestern University O'Brien Kidney National Resource Center

西北大学奥布莱恩肾脏国家资源中心

• 批准号: 10754080
• 负责人: Alfred L. George
• 金额: $ 99.21万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754080
• 关键词: Affect; American; Area; Biological Products; Biomedical Engineering; Biosensor; Budgets; California; Career Choice; Cells; Cessation of life; Chemistry; Communicable Diseases; Communication; Communities; Coupling; Dedications; Development; Diagnostic; Discipline; Disease; Education; Educational workshop; Emerging Technologies; Ensure; Event; Exposure to; Goals; High School Student; Home; Homing; Human; Image; In Vitro; Incidence; Incubators; Individual; Internships; Investigation; Ions; Kidney; Kidney Diseases; Kidney Failure; Label; Mass Spectrum Analysis; Medicare; Medicine; Mentors; Mentorship; Methods; Mission; Molecular; Monitor; Nanotechnology; Oncology; Organ; Pathogenesis; Patient Care; Persons; Pharmaceutical Preparations; Phenotype; Physiologic Monitoring; Political Factor; Proteins; Proteomics; RNA; Reagent; Renal function; Research; Research Personnel; Resource Development; Resources; Risk; Science; Scientist; Services; Skin; Structure; Students; Talents; Technology; Therapeutic; Time; Tissue imaging; Tissues; United States; Universities; Vaccines; Vision; bioelectronics; biomedical resource; cardiovascular risk factor; care costs; cell type; comorbidity; cost; design; functional genomics; gene function; gene therapy; high school program; in vivo; innovation; intercalation; kidney cell; minority communities; nanocarrier; nanoparticle; nanoscale; new technology; new therapeutic target; novel strategies; novel therapeutics; operation; physical science; programs; protein function; research and development; screening; small molecule; social factors; success; theories; therapeutic development; therapeutic target; tool

SUMMARY – NU-NRC OVERALL Kidney diseases affect 37 million Americans, placing them at major risk for cardiovascular events, other co- morbidities, and death. While there have been exciting recent advances in our field, to impact these staggering numbers, it is critical to identify new therapeutic targets, expand our understanding of disease pathogenesis and develop new methods to target specific cell types in the kidney. To do this, we must push disciplinary boundaries, build new discovery platforms and partner with orthogonal disciplines. A major unmet challenge in kidney research is the dearth of technologies and platforms that can incorporate the complexity and diversity of kidney structure, cellular phenotypes and function in their design and execution. The proposed Northwestern University National Resource Center (NU-NRC) will meet this challenge by leveraging innovations in the physical sciences to provide unique tools, reagents, and platforms to kidney researchers. By design, these resources take advantage of tissue and cellular diversity, making them powerful technologies for discovery- based kidney research and therapeutic development. The overarching theme of the NU-NRC is to adapt powerful physical sciences theory, tools, platforms, and approaches to advance kidney investigation in a Physical Sciences-Kidney Resource Center. The major goals of the Center are to A) harness physical science advances to provide new approaches to solve unmet challenges in kidney research and discovery, and B) to provide easy access to physical science tools, reagents and platforms to the broader kidney community to catalyze their research and spur innovation. We will accomplish these goals through four specific aims: 1. Establish a Biomedical Resource Core focused on established nanotechnology methods for cell-specific delivery of therapeutic and diagnostic payloads (small molecules and biologics) 2. Establish a Resource Development Core focused on nascent technologies in diverse areas of physical sciences to catalyse kidney research. 3. Establish an Administrative Core to oversee all operations of the Center and ensure new technologies are made readily available to the kidney research community and 4. Provide an immersive summer SciHigh research program for high school students. A dedicated, energetic and talented transdisciplinary scientific and administrative team at Northwestern and the University of Southern California will ensure NU-NRC fulfills its mission to transform kidney research through physical science solutions and move us closer to realizing its bold vision: physical science solutions to cure kidney diseases.

总结- NU-NRC总体 肾脏疾病影响着3700万美国人，使他们面临心血管事件的主要风险，其他共同疾病 发病和死亡虽然我们的领域最近取得了令人兴奋的进展，但要影响这些惊人的进展， 因此，确定新的治疗靶点，扩大我们对疾病发病机制的理解， 开发针对肾脏中特定细胞类型的新方法。要做到这一点，我们必须突破学科界限， 建立新的发现平台，并与正交学科合作。肾脏领域尚未解决的重大挑战 研究缺乏技术和平台，可以将肾脏的复杂性和多样性 结构、细胞表型和功能。建议西北 大学国家资源中心（NU-NRC）将通过利用创新来应对这一挑战。 为肾脏研究人员提供独特的工具，试剂和平台。通过设计，这些 资源利用组织和细胞的多样性，使它们成为发现的强大技术- 基于肾脏的研究和治疗开发。 NU-NRC的首要主题是适应强大的物理科学理论，工具，平台， 在物理科学肾脏资源中心推进肾脏研究的方法。主要 该中心的目标是：A）利用物理科学的进步，提供新的方法来解决未满足的问题 肾脏研究和发现中的挑战，以及B）提供容易获得的物理科学工具、试剂 和平台，以更广泛的肾脏社区，以促进他们的研究和刺激创新。我们将 通过四个具体目标来实现这些目标：1.建立一个生物医学资源核心， 已建立的纳米技术方法，用于细胞特异性递送治疗和诊断有效载荷（小型 分子和生物学）2.建立一个资源开发核心，重点关注以下领域的新兴技术： 物理科学的不同领域，以促进肾脏研究。3.建立一个行政核心来监督 中心的所有业务，并确保新技术随时可用于肾脏研究 社区，4。为高中生提供沉浸式的夏季SciHigh研究计划。 一个敬业，精力充沛，才华横溢的跨学科科学和管理团队在西北和 南加州大学将确保NU-NRC履行其使命，通过 物理科学解决方案，并使我们更接近实现其大胆的愿景：物理科学解决方案，以治愈 肾脏疾病