Northwestern University O'Brien Kidney National Resource Center
西北大学奥布莱恩肾脏国家资源中心
基本信息
- 批准号:10754080
- 负责人:
- 金额:$ 99.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AffectAmericanAreaBiological ProductsBiomedical EngineeringBiosensorBudgetsCaliforniaCareer ChoiceCellsCessation of lifeChemistryCommunicable DiseasesCommunicationCommunitiesCouplingDedicationsDevelopmentDiagnosticDisciplineDiseaseEducationEducational workshopEmerging TechnologiesEnsureEventExposure toGoalsHigh School StudentHomeHomingHumanImageIn VitroIncidenceIncubatorsIndividualInternshipsInvestigationIonsKidneyKidney DiseasesKidney FailureLabelMass Spectrum AnalysisMedicareMedicineMentorsMentorshipMethodsMissionMolecularMonitorNanotechnologyOncologyOrganPathogenesisPatient CarePersonsPharmaceutical PreparationsPhenotypePhysiologic MonitoringPolitical FactorProteinsProteomicsRNAReagentRenal functionResearchResearch PersonnelResource DevelopmentResourcesRiskScienceScientistServicesSkinStructureStudentsTalentsTechnologyTherapeuticTimeTissue imagingTissuesUnited StatesUniversitiesVaccinesVisionbioelectronicsbiomedical resourcecardiovascular risk factorcare costscell typecomorbiditycostdesignfunctional genomicsgene functiongene therapyhigh school programin vivoinnovationintercalationkidney cellminority communitiesnanocarriernanoparticlenanoscalenew technologynew therapeutic targetnovel strategiesnovel therapeuticsoperationphysical scienceprogramsprotein functionresearch and developmentscreeningsmall moleculesocial factorssuccesstheoriestherapeutic developmenttherapeutic targettool
项目摘要
SUMMARY – NU-NRC OVERALL
Kidney diseases affect 37 million Americans, placing them at major risk for cardiovascular events, other co-
morbidities, and death. While there have been exciting recent advances in our field, to impact these staggering
numbers, it is critical to identify new therapeutic targets, expand our understanding of disease pathogenesis and
develop new methods to target specific cell types in the kidney. To do this, we must push disciplinary boundaries,
build new discovery platforms and partner with orthogonal disciplines. A major unmet challenge in kidney
research is the dearth of technologies and platforms that can incorporate the complexity and diversity of kidney
structure, cellular phenotypes and function in their design and execution. The proposed Northwestern
University National Resource Center (NU-NRC) will meet this challenge by leveraging innovations in the
physical sciences to provide unique tools, reagents, and platforms to kidney researchers. By design, these
resources take advantage of tissue and cellular diversity, making them powerful technologies for discovery-
based kidney research and therapeutic development.
The overarching theme of the NU-NRC is to adapt powerful physical sciences theory, tools, platforms, and
approaches to advance kidney investigation in a Physical Sciences-Kidney Resource Center. The major
goals of the Center are to A) harness physical science advances to provide new approaches to solve unmet
challenges in kidney research and discovery, and B) to provide easy access to physical science tools, reagents
and platforms to the broader kidney community to catalyze their research and spur innovation. We will
accomplish these goals through four specific aims: 1. Establish a Biomedical Resource Core focused on
established nanotechnology methods for cell-specific delivery of therapeutic and diagnostic payloads (small
molecules and biologics) 2. Establish a Resource Development Core focused on nascent technologies in
diverse areas of physical sciences to catalyse kidney research. 3. Establish an Administrative Core to oversee
all operations of the Center and ensure new technologies are made readily available to the kidney research
community and 4. Provide an immersive summer SciHigh research program for high school students.
A dedicated, energetic and talented transdisciplinary scientific and administrative team at Northwestern and the
University of Southern California will ensure NU-NRC fulfills its mission to transform kidney research through
physical science solutions and move us closer to realizing its bold vision: physical science solutions to cure
kidney diseases.
总结- NU-NRC总体
肾脏疾病影响着3700万美国人,使他们面临心血管事件的主要风险,其他共同疾病
发病和死亡虽然我们的领域最近取得了令人兴奋的进展,但要影响这些惊人的进展,
因此,确定新的治疗靶点,扩大我们对疾病发病机制的理解,
开发针对肾脏中特定细胞类型的新方法。要做到这一点,我们必须突破学科界限,
建立新的发现平台,并与正交学科合作。肾脏领域尚未解决的重大挑战
研究缺乏技术和平台,可以将肾脏的复杂性和多样性
结构、细胞表型和功能。建议西北
大学国家资源中心(NU-NRC)将通过利用创新来应对这一挑战。
为肾脏研究人员提供独特的工具,试剂和平台。通过设计,这些
资源利用组织和细胞的多样性,使它们成为发现的强大技术-
基于肾脏的研究和治疗开发。
NU-NRC的首要主题是适应强大的物理科学理论,工具,平台,
在物理科学肾脏资源中心推进肾脏研究的方法。主要
该中心的目标是:A)利用物理科学的进步,提供新的方法来解决未满足的问题
肾脏研究和发现中的挑战,以及B)提供容易获得的物理科学工具、试剂
和平台,以更广泛的肾脏社区,以促进他们的研究和刺激创新。我们将
通过四个具体目标来实现这些目标:1.建立一个生物医学资源核心,
已建立的纳米技术方法,用于细胞特异性递送治疗和诊断有效载荷(小型
分子和生物学)2.建立一个资源开发核心,重点关注以下领域的新兴技术:
物理科学的不同领域,以促进肾脏研究。3.建立一个行政核心来监督
中心的所有业务,并确保新技术随时可用于肾脏研究
社区,4。为高中生提供沉浸式的夏季SciHigh研究计划。
一个敬业,精力充沛,才华横溢的跨学科科学和管理团队在西北和
南加州大学将确保NU-NRC履行其使命,通过
物理科学解决方案,并使我们更接近实现其大胆的愿景:物理科学解决方案,以治愈
肾脏疾病
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alfred L. George其他文献
High-Dose Midazolam for Pediatric Refractory Status Epilepticus: A Single-Center Retrospective Study*
高剂量咪达唑仑治疗小儿难治性癫痫持续状态:单中心回顾性研究*
- DOI:
10.1097/pcc.0000000000003043 - 发表时间:
2022 - 期刊:
- 影响因子:4.1
- 作者:
Z. S. Daniels;N. Srdanovic;K. Rychlik;Craig M. Smith;Joshua L. Goldstein;Alfred L. George - 通讯作者:
Alfred L. George
Prophecy or empiricism? Clinical value of predicting versus determining genetic variant functions
预言还是经验主义?
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:5.6
- 作者:
A. Brunklaus;Alfred L. George;D. Lal;E. Heinzen;A. Goldman - 通讯作者:
A. Goldman
Scanning mutagenesis of the voltage-gated sodium channel NasubV/sub1.2 using base editing
使用碱基编辑对电压门控钠通道 NaV1.2 进行扫描诱变
- DOI:
10.1016/j.celrep.2023.112563 - 发表时间:
2023-06-27 - 期刊:
- 影响因子:6.900
- 作者:
Juan Lorenzo B. Pablo;Savannah L. Cornett;Lei A. Wang;Sooyeon Jo;Tobias Brünger;Nikita Budnik;Mudra Hegde;Jean-Marc DeKeyser;Christopher H. Thompson;John G. Doench;Dennis Lal;Alfred L. George;Jen Q. Pan - 通讯作者:
Jen Q. Pan
Paramyotonia congenita without paralysis on exposure to cold: a novel mutation in the SCN4A gene (Val1293Ile).
先天性副肌强直,接触寒冷后不瘫痪:SCN4A 基因 (Val1293Ile) 的新突变。
- DOI:
- 发表时间:
1995 - 期刊:
- 影响因子:1.7
- 作者:
Manuela C. Koch;Karin Baumbach;Alfred L. George;Kenneth Ricker - 通讯作者:
Kenneth Ricker
Mutant Channels Contribute Ͻ50% to Na Ϩ Current in Paramyotonia Congenita Muscle
先天性副肌强直中突变通道对 Na 电流贡献 Ͻ50%
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
N. Mitrović;Alfred L. George;Reinhardt Rü Del;F. Lehmann‐Horn;H. Lerche - 通讯作者:
H. Lerche
Alfred L. George的其他文献
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{{ truncateString('Alfred L. George', 18)}}的其他基金
Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction
神经元 Na/K-ATP 酶功能障碍的细胞病理生理学
- 批准号:
10539624 - 财政年份:2022
- 资助金额:
$ 99.21万 - 项目类别:
Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction
神经元 Na/K-ATP 酶功能障碍的细胞病理生理学
- 批准号:
10646335 - 财政年份:2022
- 资助金额:
$ 99.21万 - 项目类别:
Kinetic Imaging Plate Reader for Drug Discovery and Biology
用于药物发现和生物学的动态成像读板仪
- 批准号:
10177367 - 财政年份:2021
- 资助金额:
$ 99.21万 - 项目类别:
Decrypting Variants of Uncertain Significance in Long-QT Syndrome
解密长QT综合征中不确定意义的变异
- 批准号:
10004933 - 财政年份:2020
- 资助金额:
$ 99.21万 - 项目类别:
Channelopathy-Associated Epilepsy Research Center
通道病相关癫痫研究中心
- 批准号:
10477447 - 财政年份:2018
- 资助金额:
$ 99.21万 - 项目类别:
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