注射可能な吸収性ゲルのドラッグデリバリーシステムの開発－低侵襲の新規骨造成法

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OBJECTIVES : To achieve ideal functional and aesthetic requirements, ridge augmentation is often required before dental implant placement. Bone augmentation (especially vertical), which normally consists of complex and invasive surgeries, still remains challenge. This study seeks to investigate the feasibility of an injectable in situ gel-forming system containing strontium hydroxyapatite (SrHA) and alginate (Alg) and also evaluate the addition of simvastatin (SIM) in the SrHA-Alg system as a stimulant to further enhance bone formation in the minimally invasive manner.MATERIAL AND METHODS : SrHA-Alg-SIM solution was prepared with low, medium and high doses of SIM according to the previous protocol, and each animal received a 200-μL single subperiosteal injection of either SrHA-Alg-SIM solution or SrHA-Alg solution alone as control. The new bone formation was assessed at 0, 4, and 8 weeks histologically and radiologically.RESULTS : The SrHA-alginate solution materials could form solid gel once injected. As such, no sutures were required to close the injection site. Significantly greater amount of new bone formation was observed in the SrHA-Alg-SIM (Low dose) group compared with the other groups both by micro-CT and by histological section.CONCLUSIONS : Rat calvarial bone augmentation was achieved by a single subperiosteal injection of SrHA-Alg-SIM solution without any administration of stem cells or growth factors. The low dose of simvastatin incorporated seemed to have the best stimulatory effect in bone formation. The in situ gel-forming material may hold potential therapeutic benefits for local bone augmentation in a minimally invasive manner.