Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment

转移性脊柱肿瘤:微创骨折风险分析和治疗

基本信息

  • 批准号:
    7428992
  • 负责人:
  • 金额:
    $ 42.36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-04-01 至 2013-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The identification of cancer metastases to the bony vertebral column obligates the treating clinician to make a surgical decision. The consequences of that decision for the patient are significant whether the recommendation is for surgical or non-surgical treatment. If the spine is deemed unstable and at risk for fracture, then the patient will undergo a major spinal operation, and will often spend much of their remaining life recuperating from it. Conversely, the patient whose spine is deemed stable and receives non-surgical treatment risks fracture and possible paralysis if the stability analysis was incorrect. In addition, the metastatic disease usually progresses, and the stability analysis must be repeated at intervals throughout the disease course. The spinal stability decision is empirical and can be inaccurate, even when done by experienced spinal clinicians. This proposal addresses both the stability decision and, for those patients deemed at risk for fracture, the nature of the treatment. Aim 1 describes the development of an automated program that analyzes spinal computerized tomography scans, and calculates the residual load carrying capacity of the affected vertebra. Aim 2 optimizes novel injectable materials to restore the load carrying capacity of the vertebra in a minimally invasive manner, thus decreasing time in recovery and rehabilitation from major spine surgery. Successful achievement of this aim would offer an alternative to open surgery for many of these patients, thus decreasing their rehabilitation time and increasing their family time. Aim 3 addresses validation of both the automated spinal stability analysis and the minimally invasive spinal reconstruction. These in vitro and in vivo Aim 3 preclinical validation studies are requisite steps to position both the Aim 1 automated diagnostic methodology and the Aim 2 minimally invasive surgical treatment methodology closer to the goal of translation to clinical practice. Public Health Relevance Statement (provided by applicant): The computerized spinal stability assessment, for patients who have cancer that has spread to their spine, will offer more accurate diagnosis of the need for spine surgery to the patients, and with a much greater likelihood that the patients and their families can get the evaluation done near their home, saving them time, expense, and inconvenience. The recommendation for non-surgical treatment will be made with increased assurance that the risk of a spine fracture is low. Those patients, who do need surgery, will often chose minimally invasive surgical techniques that will shorten their hospital stay and allow them to return home to their families.
描述(由申请人提供):肿瘤转移到骨性脊柱的鉴定使治疗临床医生有义务做出手术决定。该决定对患者的影响是显著的,无论推荐手术或非手术治疗。如果认为脊柱不稳定,有骨折的危险,那么患者将接受一次大的脊柱手术,并且通常要花很长时间从手术中恢复过来。相反,如果稳定性分析不正确,认为脊柱稳定并接受非手术治疗的患者有骨折和可能瘫痪的风险。此外,转移性疾病通常会进展,稳定性分析必须在整个病程中间隔重复。脊柱稳定性的决定是经验性的,可能是不准确的,即使是由经验丰富的脊柱临床医生完成的。本建议既解决了稳定性的问题,也解决了那些被认为有骨折风险的患者的治疗性质。目标1描述了一种自动化程序的开发,该程序可以分析脊柱计算机断层扫描,并计算受影响椎体的剩余承载能力。目的2优化新型注射材料,以微创方式恢复椎体的承载能力,从而减少大脊柱手术后的恢复和康复时间。这一目标的成功实现将为许多患者提供开放手术的替代方案,从而减少他们的康复时间并增加他们的家庭时间。目的3讨论了自动脊柱稳定性分析和微创脊柱重建的验证。这些体外和体内的Aim 3临床前验证研究是使Aim 1自动诊断方法和Aim 2微创手术治疗方法更接近于转化为临床实践目标的必要步骤。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Lichun Lu其他文献

Lichun Lu的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Lichun Lu', 18)}}的其他基金

Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
  • 批准号:
    10089684
  • 财政年份:
    2019
  • 资助金额:
    $ 42.36万
  • 项目类别:
Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
  • 批准号:
    9908051
  • 财政年份:
    2019
  • 资助金额:
    $ 42.36万
  • 项目类别:
Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
  • 批准号:
    10364656
  • 财政年份:
    2019
  • 资助金额:
    $ 42.36万
  • 项目类别:
Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
  • 批准号:
    10444098
  • 财政年份:
    2019
  • 资助金额:
    $ 42.36万
  • 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
  • 批准号:
    7796565
  • 财政年份:
    2008
  • 资助金额:
    $ 42.36万
  • 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
  • 批准号:
    8088220
  • 财政年份:
    2008
  • 资助金额:
    $ 42.36万
  • 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - Master
转移性脊柱肿瘤:微创骨折风险分析和治疗 - 硕士
  • 批准号:
    8963947
  • 财政年份:
    2008
  • 资助金额:
    $ 42.36万
  • 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
  • 批准号:
    8244358
  • 财政年份:
    2008
  • 资助金额:
    $ 42.36万
  • 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
  • 批准号:
    7599113
  • 财政年份:
    2008
  • 资助金额:
    $ 42.36万
  • 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - Master
转移性脊柱肿瘤:微创骨折风险分析和治疗 - 硕士
  • 批准号:
    10585673
  • 财政年份:
    2008
  • 资助金额:
    $ 42.36万
  • 项目类别:

相似海外基金

Collaborative Research: Using Adaptive Lessons to Enhance Motivation, Cognitive Engagement, And Achievement Through Equitable Classroom Preparation
协作研究:通过公平的课堂准备,利用适应性课程来增强动机、认知参与和成就
  • 批准号:
    2335802
  • 财政年份:
    2024
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Standard Grant
Collaborative Research: Using Adaptive Lessons to Enhance Motivation, Cognitive Engagement, And Achievement Through Equitable Classroom Preparation
协作研究:通过公平的课堂准备,利用适应性课程来增强动机、认知参与和成就
  • 批准号:
    2335801
  • 财政年份:
    2024
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Standard Grant
A Longitudinal Study of the Relationship between Participation in a Comprehensive Exercise Program and Academic Achievement
参加综合锻炼计划与学业成绩之间关系的纵向研究
  • 批准号:
    24K14615
  • 财政年份:
    2024
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Collaborative Research: Characterizing Best Practices of Instructors who Have Narrowed Performance Gaps in Undergraduate Student Achievement in Introductory STEM Courses
合作研究:缩小本科生 STEM 入门课程成绩差距的讲师的最佳实践
  • 批准号:
    2420369
  • 财政年份:
    2024
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Standard Grant
Collaborative Research: Using Adaptive Lessons to Enhance Motivation, Cognitive Engagement, And Achievement Through Equitable Classroom Preparation
协作研究:通过公平的课堂准备,利用适应性课程来增强动机、认知参与和成就
  • 批准号:
    2335800
  • 财政年份:
    2024
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Standard Grant
WTG: Diffusion of Research on Supporting Mathematics Achievement for Youth with Disabilities through Twitter Translational Visual Abstracts
WTG:通过 Twitter 翻译视觉摘要传播支持残疾青少年数学成就的研究
  • 批准号:
    2244734
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Standard Grant
The Impact of Emotional Experiences of Pride on Long-Term Goal Achievement Behaviors in Elite Athletes
骄傲的情感体验对优秀运动员长期目标实现行为的影响
  • 批准号:
    23K16740
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Meta-Analysis of the Instructional-Relational Model of Student Engagement and Math Achievement: A Moderation and Mediation Approach
学生参与度和数学成绩的教学关系模型的元分析:一种调节和中介方法
  • 批准号:
    2300738
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Standard Grant
Improving maths achievement in children with speech, language, and communication needs through 'collaborative vocabulary teaching'
通过“协作词汇教学”提高有言语、语言和交流需求的儿童的数学成绩
  • 批准号:
    2890475
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Studentship
HSI Institutional Transformation Project: Retention and Achievement for Introductory STEM English Learners (RAISE)
HSI 机构转型项目:STEM 英语入门学习者的保留和成就 (RAISE)
  • 批准号:
    2225178
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
    Continuing Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了