Minimally Invasive On Demand Electrical Nerve Block (OD-ENB) Device for Peripheral Pain

用于治疗周围疼痛的微创按需电神经阻滞 (OD-ENB) 装置

• 批准号: 10482175
• 负责人: Tina Louise Vrabec
• 金额: $ 26.04万
• 依托单位: H-CUBED, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10482175
• 关键词: Acute Pain; Address; Adult; Adverse effects; Affect; Aging; Analgesics; Anesthetics; Area; Arthritis; Carbon; Caring; Charge; Chronic; Clinical; Degenerative polyarthritis; Development; Device Safety; Device or Instrument Development; Devices; Disease; Dose; Elderly; Electric Capacitance; Electrodes; Electrolytes; Environment; Evaluation; Family; Fiber; Health; Health Services Accessibility; Home Nursing Care; Implant; In Vitro; Individual; Injectable; Intervention; Knee Osteoarthritis; Liquid substance; Locales; Location; Materials Testing; Medical; Medicine; Methods; Modality; Modeling; Morphology; Motor; Narcotics; Nerve; Nerve Block; Nitrogen; Nociception; Obesity; Operative Surgical Procedures; Opioid; Oxygen; Pain; Pain management; Patients; Peripheral; Peripheral Nerves; Peroxonitrite; Pharmacological Treatment; Physical Function; Population; Postoperative Pain; Predisposition; Prevalence; Procedures; Quality of life; Ramp; Rattus; Reaction; Reflex action; Rural; Saline; Specificity; Superoxides; Surface; System; Technology; Testing; Time; Tissues; Toxic effect; Transportation; Variant; Visit; Weight; Weight-Bearing state; Work; chronic pain; chronic pain management; clinically significant; design; dosage; efficacy testing; functional disability; in vitro testing; in vivo; in vivo evaluation; knee replacement arthroplasty; minimally invasive; nerve damage; neural; neuroregulation; novel; older patient; opioid use; osteoarthritis pain; pain relief; pain symptom; perhydroxyl radical; peripheral pain; pharmacologic; platinum electrode; prevent; prototype; response; safety testing; side effect; success; young adult

Knee  Osteoarthritis  (KOA)  is  a  degenerative  joint  disease  that  leads  to  significant  pain  and  functional  disability  affecting  over  30%  of  older  adults  making  it  one  of  the  most  common  and  debilitating  conditions  related  to  aging.  This  disease  results  in  a  loss  of  mobility,  reduced  quality  of  life,  and  increased  likelihood  of  a  need  for  nursing  home  care.   Reduced  mobility  represents  a  downward  spiral  for  elderly  individuals  that  impacts  overall  health  and  the  ability  to  interact  with  their  environment  and  families.  In  addition  to  aging,  the  prevalence  of  obesity  in  the  overall  population  increases  the  likelihood  of  this  condition  in  younger  individuals  impacting  their  long-­‐term  health  and  their  participation  in  the  workforce.  KOA  patients  have  significant  pain  with  weight  bearing,  poor  physical  function,  and  widely  variable  response  rates  to  pharmacological  and  invasive  treatments.  In  addition,  KOA  patients  are  highly  susceptible  to  chronic  opioid  use.  Clinicians  are  continuously  looking  for  alternative  interventions  in  patients  that  have  failed  conservative  therapy.  These  interventions  should  have  less  adverse  effects,  be  less  invasive  and  expensive  than  knee  arthroplasty  (which  also  has  significant  persistent  postsurgical  pain).  One  common  alternative  option  to  analgesics  or  opioids  is  anesthetic  nerve  blocks  to  reduce  both  acute  and  chronic  pain.  However,  anesthetic  nerve  blocks  require  a  visit  to  a  doctor’s  office  preventing  the  patient  from  obtaining  the  pain  relief  immediately  when  it  is  needed,  and  limiting  access  to treatment for patients with transportation issues.  On  demand  electrical  nerve  block  (OD-­‐ENB),  is  a  means  of  electrically  anesthetizing  a  peripheral  nerve  for  the  treatment  of  chronic  pain  and  other  disorders.  The  use  of  an  OD-­‐ENB  device  would  provide  the  patient  the  ability  to  immediately  suppress  their  pain  symptoms.  Further,  because  the  technology  is  based  on  the  fundamental  principle  of  electrical nerve block, there are no short or long-­‐term side-­‐effects other than the inactivation of the targeted nerve. The  treatment  is  completely  non-­‐addicting  and  thus  provides  an  excellent  alternative  to  pharmacological  treatments.  In  addition,  dosing  with  the  ON-­‐ENB  system  is  not  limited  because  there  are  no  dose-­‐related  toxicity  effects.  Our  current  proposal  would  involve  the  development  of  a  miniature  nerve  block  device  that  could  be  injected  next  to  the  nerve  to  provide  localized  nerve  block.  The  device  would  be  externally  powered  under  the  control  of  the  user  and  a  single  external control unit could power more than one device. This makes it an ideal solution for treatment of KOA.

膝骨关节炎（KOA）是一种退行性关节疾病，会导致明显的疼痛和功能障碍