Minimally Invasive On Demand Electrical Nerve Block (OD-ENB) Device for Peripheral Pain
用于治疗周围疼痛的微创按需电神经阻滞 (OD-ENB) 装置
基本信息
- 批准号:10482175
- 负责人:
- 金额:$ 26.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:Acute PainAddressAdultAdverse effectsAffectAgingAnalgesicsAnestheticsAreaArthritisCarbonCaringChargeChronicClinicalDegenerative polyarthritisDevelopmentDevice SafetyDevice or Instrument DevelopmentDevicesDiseaseDoseElderlyElectric CapacitanceElectrodesElectrolytesEnvironmentEvaluationFamilyFiberHealthHealth Services AccessibilityHome Nursing CareImplantIn VitroIndividualInjectableInterventionKnee OsteoarthritisLiquid substanceLocalesLocationMaterials TestingMedicalMedicineMethodsModalityModelingMorphologyMotorNarcoticsNerveNerve BlockNitrogenNociceptionObesityOperative Surgical ProceduresOpioidOxygenPainPain managementPatientsPeripheralPeripheral NervesPeroxonitritePharmacological TreatmentPhysical FunctionPopulationPostoperative PainPredispositionPrevalenceProceduresQuality of lifeRampRattusReactionReflex actionRuralSalineSpecificitySuperoxidesSurfaceSystemTechnologyTestingTimeTissuesToxic effectTransportationVariantVisitWeightWeight-Bearing stateWorkchronic painchronic pain managementclinically significantdesigndosageefficacy testingfunctional disabilityin vitro testingin vivoin vivo evaluationknee replacement arthroplastyminimally invasivenerve damageneuralneuroregulationnovelolder patientopioid useosteoarthritis painpain reliefpain symptomperhydroxyl radicalperipheral painpharmacologicplatinum electrodepreventprototyperesponsesafety testingside effectsuccessyoung adult
项目摘要
Knee Osteoarthritis (KOA) is a degenerative joint disease that leads to significant pain and functional disability
affecting over 30% of older adults making it one of the most common and debilitating conditions related to aging. This
disease results in a loss of mobility, reduced quality of life, and increased likelihood of a need for nursing home care.
Reduced mobility represents a downward spiral for elderly individuals that impacts overall health and the ability to
interact with their environment and families. In addition to aging, the prevalence of obesity in the overall population
increases the likelihood of this condition in younger individuals impacting their long-‐term health and their participation
in the workforce. KOA patients have significant pain with weight bearing, poor physical function, and widely variable
response rates to pharmacological and invasive treatments. In addition, KOA patients are highly susceptible to chronic
opioid use. Clinicians are continuously looking for alternative interventions in patients that have failed conservative
therapy. These interventions should have less adverse effects, be less invasive and expensive than knee arthroplasty
(which also has significant persistent postsurgical pain). One common alternative option to analgesics or opioids is
anesthetic nerve blocks to reduce both acute and chronic pain. However, anesthetic nerve blocks require a visit to a
doctor’s office preventing the patient from obtaining the pain relief immediately when it is needed, and limiting access
to treatment for patients with transportation issues.
On demand electrical nerve block (OD-‐ENB), is a means of electrically anesthetizing a peripheral nerve for the
treatment of chronic pain and other disorders. The use of an OD-‐ENB device would provide the patient the ability to
immediately suppress their pain symptoms. Further, because the technology is based on the fundamental principle of
electrical nerve block, there are no short or long-‐term side-‐effects other than the inactivation of the targeted nerve. The
treatment is completely non-‐addicting and thus provides an excellent alternative to pharmacological treatments. In
addition, dosing with the ON-‐ENB system is not limited because there are no dose-‐related toxicity effects. Our current
proposal would involve the development of a miniature nerve block device that could be injected next to the nerve to
provide localized nerve block. The device would be externally powered under the control of the user and a single
external control unit could power more than one device. This makes it an ideal solution for treatment of KOA.
膝关节骨性关节炎是一种退行性关节疾病,可导致严重的疼痛和功能障碍
影响超过30%的老年人,使其成为与衰老有关的最常见和最令人衰弱的疾病之一。
疾病导致丧失活动能力、降低生活质量和增加需要疗养院护理的可能性。
行动不便是老年人的一种螺旋式下降,影响整体健康和生活能力。
与他们的环境和家庭相互作用。除了老龄化,
增加了年轻人发生这种情况的可能性,影响他们的长期健康和参与
KOA患者在负重时有明显的疼痛,身体功能差,
对药物和侵入性治疗的反应率。此外,KOA患者对慢性
阿片类药物的使用。临床医生一直在寻找替代干预措施,在病人已经失败的保守治疗。
这些干预措施应该有较少的副作用,侵入性小,比膝关节置换术昂贵
(也有明显的持续性术后疼痛)。镇痛药或阿片类药物的一种常见替代选择是
麻醉神经阻滞,以减少急性和慢性疼痛。然而,麻醉神经阻滞需要访问一个
医生办公室阻止患者在需要时立即获得疼痛缓解,并限制访问
为有交通问题的病人提供治疗
按需电神经阻滞(OD-ENB)是一种电麻醉周围神经的方法,用于治疗神经麻痹。
使用OD-ENB器械将使患者能够
立即抑制他们的疼痛症状。此外,由于该技术是基于基本原理,
电神经阻滞,除了目标神经的失活之外,没有短期或长期的副作用。
治疗是完全非成瘾性的,因此提供了药物治疗的极好替代方案。
此外,ON-ENB系统的剂量不受限制,因为没有剂量依赖性毒性效应。
一项提案将涉及开发一种微型神经阻滞装置,可以注射到神经旁边,
提供局部神经阻滞。该设备将在用户的控制下由外部供电,
外部控制单元可以为多个设备供电。这使得它成为治疗KOA的理想解决方案。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tina Louise Vrabec其他文献
Tina Louise Vrabec的其他文献
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{{ truncateString('Tina Louise Vrabec', 18)}}的其他基金
Nest#4-Nerve Excitation Control Through AC Regulation (NECTAR)
巢
- 批准号:
10701822 - 财政年份:2022
- 资助金额:
$ 26.04万 - 项目类别:
Nest#4-Nerve Excitation Control Through AC Regulation (NECTAR)
巢
- 批准号:
10549471 - 财政年份:2022
- 资助金额:
$ 26.04万 - 项目类别:
Investigation of Partial Electrical Nerve Block for Autonomic Regulation
自主调节部分电神经阻滞的研究
- 批准号:
10323259 - 财政年份:2020
- 资助金额:
$ 26.04万 - 项目类别:
Investigation of Partial Electrical Nerve Block for Autonomic Regulation
自主调节部分电神经阻滞的研究
- 批准号:
10080757 - 财政年份:2020
- 资助金额:
$ 26.04万 - 项目类别:
Investigation of Partial Electrical Nerve Block for Autonomic Regulation
自主调节部分电神经阻滞的研究
- 批准号:
10542814 - 财政年份:2020
- 资助金额:
$ 26.04万 - 项目类别:
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