硬膜外通電による末梢血流動態と除痛効果

硬膜外通电的外周血流动力学及镇痛效果

• 批准号: 08771176
• 负责人: 早津 恵子
• 金额: $ 0.7万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-08771176/
• 关键词: 硬膜外通電; 筋酸素動態; 近赤外線; 除痛効果; 低頻度刺激; 高頻度刺激

四肢に慢性疼痛を有する患者15例を対象とした.本研究の主旨に同意をえて,疼痛部位に一致した分節性筋収縮が得られるように硬膜外刺激電極を装入した.刺激による分節性筋収縮の観察できる部位に筋組織内酸素動態をの近赤外線モニタープローベを装着し,酸素化ヘモグロビン(HbO2),還元ヘモグロビン(Hb),total Hb,チトクロームaa3(Ctaa3)の変化を評価した。室温27℃で低頻度刺激(1-5Hz)を30分おこなった.15例全例で刺激開始1分で,酸素化ヘモグロビン(HbO2)とtotal Hb(HbO2+Hb)の上昇が観察された.最高値の平均でHbO24.0μMOL,total Hb4.2μMOLの上昇が観察された.同様に高頻度刺激(120Hz)を行ったところ,HbO2とtotal Hbの上昇が観察されたが,その上昇勾配は緩やかで,最高値の平均でHbO2 1.7μMOL,totalHb 1.9μMOLと,低頻度刺激に比較すると上昇程度が低かった.いずれの刺激条件でもHbとCtaa3は変化しなかった.また同時に深部温を測定したが,全例で刺激前より1時間後では,平均0.8℃の上昇がみられた.高頻度と低頻度では温度上昇は差異がなかった.除通効果は15例中12例(80%)で,低頻度刺激のほうが有効であった.高頻度刺激は刺激開始直後に一過性に電撃痛様の痛みを訴えたものが15例中10例あった.その後はペインスコアで変化がなかったものが8例,70%以上の除痛は1例,30〜70%が4例,30%以下が2例であった.一方,低頻度刺激では,70%以上が4例,30〜70%が7例,30%以下が4例であった.

15 cases of patients with chronic pain in the limbs were treated by the patient. The purpose of this study is agreed with the purpose of this study, pain. The location is the same, the segmental tendon contraction is achieved, the epidural stimulation electrode is installed, and the stimulation is done. Observation of segmental tendon contraction and acid dynamics in tendon tissue at the site of segmental tendon contraction HbO2,HbO2,HbO2,total Hb. Low-frequency stimulation (1-5Hz) at room temperature of 27℃ was performed for 30 minutes. All 15 cases were stimulated for 1 minute, acidified HbO2 and total The rise of Hb(HbO2+Hb) is the highest value. The average value is HbO24.0μMOL, total Hb4.2μMOL rises and rises, HbO2 total Hb のrise が観看されたが, そのrise compatibility は やかで, the highest value のaverage でHbO2 1.7μMOL, totalHb 1.9μMOL, low-frequency stimulation, relatively low rise rate, stimulation strip The parts are Hb and Ctaa3 and the temperature is changed and the deep temperature is measured at the same time. The whole example is Before and after stimulation, there was an average rise of 0.8°C. There was a difference in temperature rise between high frequency and low frequency. The elimination effect was found in 12 out of 15 cases (80%), and there was a difference in temperature rise under low frequency stimulation. It is effective. High-frequency stimulation does not cause transient electrical pain after the stimulation starts.が15 cases, 10 cases, その后はペインスコアで変化, 8 cases, 70 1 case of pain relief was above %, 4 cases were between 30% and 70%, and 2 cases were below 30%. On the other hand, low-frequency stimulation was effective, 4 cases were above 70%, 7 cases were between 30% and 70%, and 4 cases were below 30%.

项目成果

早津恵子: "電気鎮痛" Clinical Neuroscience. 14(9). 1051-1053 (1996)

Keiko Hayatsu：“电镇痛”临床神经科学 14(9) 1051-1053 (1996)。