Role of volume-regulated anion channels (VRACs) in kidney integrity (B02)

容量调节阴离子通道 (VRAC) 在肾脏完整性中的作用 (B02)

• 批准号: 418374405
• 金额: --
• 依托单位: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418374405?language=en
• 关键词: Role; volume; regulated; anion; channels

The volume-regulated anion channel VRAC, recently identified by us to be formed by LRRC8 heteromers, has important roles in cell volume regulation, apoptosis, and probably transepithelial transport. An important role of VRAC in the maintenance of kidney integrity is inferred by renal tubular degeneration upon VRAC disruption. Extrapolating from VRAC’s likely role in brain and cardiac ischemia, we assume that it importantly modulates ischemia-reperfusion injury (IRI) in the kidney. Through analysis in different mouse models, we will localize all 5 LRRC8 subunits in the kidney, investigate their physiological roles in tubular processes, and will clarify their role in IRI. VRAC may turn out to be a novel target for treating kidney injury.

我们最近发现体积调节阴离子通道 VRAC 由 LRRC8 异聚体形成，在细胞体积调节、细胞凋亡以及可能的跨上皮转运中具有重要作用。 VRAC 破坏时肾小管变性推断 VRAC 在维持肾脏完整性中的重要作用。从 VRAC 在脑和心脏缺血中可能的作用推断，我们假设它对肾脏缺血再灌注损伤 (IRI) 具有重要调节作用。通过对不同小鼠模型的分析，我们将定位肾脏中的所有 5 个 LRRC8 亚基，研究它们在肾小管过程中的生理作用，并阐明它们在 IRI 中的作用。 VRAC 可能成为治疗肾损伤的新靶点。