The polyamine system in gender-related renoprotection (B05)

性别相关肾脏保护中的多胺系统（B05）

• 批准号: 418383255
• 金额: --
• 依托单位: Institut für Vegetative Physiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/418383255?language=en
• 关键词: polyamine; system; gender; related; renoprotection

We will investigate how changes in the polyamine system contribute to the gender-dependent susceptibility to AKI. To recognize the influence of sex-related polyamine levels on the outcome of AKI, we will expose male mice with and without gonadectomy and female mice with and without testosterone treatment to renal IRI. Polyamine production and breakdown in these animals will be blocked to explore whether gender-dependent differences in the outcome of AKI can be attenuated by pharmacologic inhibition of the polyamine system. Furthermore, murine embryonic kidney explants and zebrafish larvae will be used as screening tools to investigate how testosterone interferes with prospective drugs targeting the homeostasis of polyamines for renoprotection.

我们将调查多胺系统的变化如何有助于性别相关的AKI易感性。为了认识与性别相关的多胺水平对AKI结局的影响，我们将雄性小鼠和雌性小鼠分别进行性腺切除和性腺切除，并对雌性小鼠进行肾IRI治疗。多胺在这些动物中的产生和分解将被阻断，以探索AKI结果中的性别差异是否可以通过对多胺系统的药物抑制来减弱。此外，小鼠胚胎肾脏外植体和斑马鱼幼虫将被用作筛选工具，以研究睾酮如何干扰以多胺动态平衡为目标的预期药物以保护肾脏。