Northern California Acute Care Research Consortium (NORCARES)

创新EmeRgENcy Care临床试验网络（SIREN）的创建旨在开展高质量的多中心临床试验，以改善神经系统、心脏、呼吸系统、血液系统和创伤紧急事件患者的结局。在本申请中，我们建议将北方加州急性护理研究联盟（NORCARES）作为新的SIREN中心，具有Co-Hub和M-PI结构，包括加州大学戴维斯分校（丹尼尔，医学博士，MAS）、斯坦福大学（Karen Hirsch，医学博士）和加州大学旧金山分校弗朗西斯科（Robert Rodriguez，医学博士）。这三个机构和PI非常适合领导一个中心，在过去20年中，他们的研究项目和生产力都表现出了广泛和持续的增长，拥有强大的研究基础设施，以促进患者参加试验。NORCARES包括北方加州和邻近地区的30个辐条和7个EMS系统，我们的调查人员以前曾与他们合作。我们选择了具有丰富研究经验和基础设施的辐条和EMS机构，利用具有不同种族和民族背景，城市和农村地理以及学术和社区医院的大量患者。每年在整个NORCARES中心，有超过180万次艾德就诊，520，000次院前911现场运输和21，000次创伤入院。与美国人口相比，我们的中心为黑人、亚洲人、夏威夷原住民和太平洋岛民以及西班牙裔艾德患者提供更大比例的服务。我们将确保NORCARES为我们的辐条和EMS机构提供坚实的研究基础设施，培训和监督。我们的中心将招募大量的研究受试者，保持良好的临床实践，遵守研究法规，并遵守质量控制活动。我们将在所有研究活动中与其他SIREN中心、数据协调中心、临床协调中心和联邦合作伙伴合作。我们将实施一项创新的初级教师培训计划，将初级学者转变为试验研究者，能够设计和领导紧急护理试验。我们将努力促进妇女和少数民族医学教师的职业生涯，他们占我们关键人员的44%。凭借出色的基础设施和创新的合作计划，我们拟议的中心具有独特的优势，可以提高SIREN试验的入学率，并促进患者人群和教师的公平性和多样性。

The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) was created to enable conduct of high-quality, multicenter clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, hematologic, and trauma emergency events. In this application, we propose the Northern California Acute Care Research Consortium (NORCARES) as a new SIREN Hub, with a Co-Hub and M-PI structure that includes UC Davis (Daniel Nishijima, MD, MAS), Stanford (Karen Hirsch, MD), and UC San Francisco (Robert Rodriguez, MD). These three institutions and PIs are well suited to lead a Hub, having demonstrated broad and sustained growth in their research programs and productivity over the past 20 years with robust research infrastructure to facilitate patient enrollment into trials. NORCARES includes 30 Spokes and 7 EMS systems across Northern California and adjacent areas with whom our investigators have previously collaborated. We have selected Spokes and EMS agencies with extensive research experience and infrastructure, drawing on large patient volumes with diverse racial and ethnic backgrounds, urban and rural geography, and academic and community hospitals. Annually across the NORCARES Hub, there are over 1.8 million ED visits, 520,000 prehospital 911 scene transports, and 21,000 trauma admissions. Compared to the US population, our Hub serves larger proportions of Black, Asian, Native Hawaiian and Pacific Islander, and Hispanic ED patients. We will ensure that NORCARES provides solid research infrastructure, training and oversight to our Spokes and EMS agencies. Our Hub will enroll substantial numbers of research subjects, maintain Good Clinical Practices, adhere to research regulations, and comply with quality control activities. We will collaborate with the other SIREN Hubs, the Data Coordinating Center, the Clinical Coordinating Center, and federal partners in all research activities. We will implement an innovative Junior Faculty Training Program to transform junior scholars into trial investigators, capable of designing and leading emergency care trials. We will seek to promote the careers of women and under-represented minorities in medicine faculty, who constitute 44% of our key personnel. With outstanding infrastructure and an innovative collaborative plan, our proposed Hub is uniquely positioned to boost enrollment and promote equity and diversity of patient populations and faculty in SIREN trials.