Circadian control of microbial function in chronic intestinal inflammation (P03#)

内在生物钟的紊乱，例如，轮班工人的内外白天不匹配，以及微生物区系失调，都会促进炎症性肠病(IBD)的发展。该项目研究哪种时钟控制微生物区系组成和功能随白天变化的波动。在与IBD相关的小鼠模型中，生物群从时钟缺陷小鼠的转移将检验微生物区系波动的丧失是否在IBD的发展中起关键作用的假设。在与IBD相关的小鼠模型中，通过限时喂养恢复结肠时钟将决定肠道时钟是否可以成为未来治疗策略的目标。

Disruption of intrinsic clocks, e.g. by mismatch of the external and internal daytime in shift workers, as well as microbiota dysbiosis promote the development of inflammatory bowel diseases (IBD). This project examines which clock controls daytime-dependent fluctuations in microbiota composition and function. Microbiota transfer from clock-deficient mice in IBD-relevant mouse models will test the hypothesis whether the loss of microbiota fluctuations plays a key role in the development of IBD. Restoring the colon clock in an IBD-relevant mouse model by time-restricted feeding will determine whether the intestinal clock can be a target for future treatment strategies.